Simon F, Porte J, Verdier F, Guigon D, Drouville C, Le Bras J
Centre National de Référence de la Chimiosensibilité du Paludisme, Hôpital Claude-Bernard, Paris.
Bull Soc Pathol Exot Filiales. 1987;80(3 Pt 2):417-25.
The study by an isotopic semi-microtest of the sensitivity of 44 P. falciparum strains isolated from Congolese children living in Pointe-Noire demonstrated a high prevalence of chloroquine resistance and partial cross resistance to monodesethylamodiaquine. The sensitivity to quinine was high except for 3 isolates. The assay of amino-4-quinolines by H. P. L. C. on 37 subjects revealed the extent of self-treatment and drug-pressure in this population. A 3-day treatment with 25 mg/kg of chloroquine or amodiaquine in 24 subjects resulted in the disappearance of clinical symptoms in all patients and a parasitological cure on day 7 in 75%. The partial maintenance of efficacy of amino-4-quinolines in this chloroquine-resistant region implies that chloroquine and amodiaquine can be used as first choice drugs for uncomplicated acute malaria, but on condition that the levels of resistance and transmission are monitored.
对从黑角市的刚果儿童中分离出的44株恶性疟原虫进行同位素半微量试验的研究表明，氯喹耐药性以及对单去乙基阿莫地喹的部分交叉耐药性普遍存在。除3株分离株外，对奎宁的敏感性较高。通过高效液相色谱法对37名受试者进行的4-氨基喹啉检测揭示了该人群自我治疗和药物压力的程度。对24名受试者采用25mg/kg氯喹或阿莫地喹进行为期3天的治疗，所有患者的临床症状均消失，75%的患者在第7天实现了寄生虫学治愈。在这个氯喹耐药地区，4-氨基喹啉的疗效部分维持，这意味着氯喹和阿莫地喹可作为非复杂性急性疟疾的首选药物，但前提是要监测耐药水平和传播情况。
