Sharifi-Rad Javad, Kamiloglu Senem, Yeskaliyeva Balakyz, Beyatli Ahmet, Alfred Mary Angelia, Salehi Bahare, Calina Daniela, Docea Anca Oana, Imran Muhammad, Anil Kumar Nanjangud Venaktesh, Romero-Román Maria Eugenia, Maroyi Alfred, Martorell Miquel
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Science and Technology Application and Research Center (BITAUM), Bursa Uludag University, Bursa, Turkey.
Front Pharmacol. 2020 Oct 22;11:571459. doi: 10.3389/fphar.2020.571459. eCollection 2020.
Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: "Psoralidin" or "therapeutic effects" or "biological activity" or "" in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.
对补骨脂素（一种来自补骨脂（L.）Medik.种子的生物活性化合物）的药理特性和分子机制的最相关研究分析证实了其复杂的治疗潜力。在过去几年中，科学界对补骨脂素的兴趣有所增加，尤其是在发现其在雌激素相关疾病中的益处以及作为化学预防剂之后。越来越多的临床前证据表明，补骨脂素具有抗癌、抗骨质疏松、抗炎、抗白癜风、抗菌、抗病毒和抗抑郁样作用。在此，我们对补骨脂素的生物利用度、药理活性进行了全面且批判性的综述，重点关注分子机制和细胞信号通路。在本综述中，我们使用以下关键词在PubMed数据库上进行了文献研究：“补骨脂素”或“治疗效果”或“生物活性”或“”，以便根据临床前实验研究确定关于补骨脂素生物利用度和不同疾病治疗效果机制的相关研究。鉴于补骨脂素对人类健康的有益作用，本文收集了其药物治疗效果的完整信息，并为慢性病开辟了新的天然治疗前景。
