Zhang Zhen-Dong, Huang Mei-Zhou, Yang Ya-Jun, Liu Xi-Wang, Qin Zhe, Li Shi-Hong, Li Jian-Yong
Key Lab of New Animal Drug Project of Gansu Province, Key Lab of Veterinary Pharmaceutical Development of Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou, China.
Front Physiol. 2020 Oct 22;11:582801. doi: 10.3389/fphys.2020.582801. eCollection 2020.
Aspirin eugenol ester (AEE) is a new potential drug with anti-inflammatory and antioxidant stress pharmacological activity. Paraquat (PQ) is an effective and commercially important herbicide that is widely used worldwide. However, paraquat is highly toxic and can cause various complications and acute organ damage, such as liver, kidney and lung damage. The purpose of this study was to investigate whether AEE has a protective effect on hepatotoxicity induced by PQ and . Cell viability, apoptosis rate, mitochondrial function and intracellular oxidative stress were detected to evaluate the protective effect of AEE on PQ-induced BRL-3A (normal rat hepatocytes) cytotoxicity . , AEE pretreatment could attenuate oxidative stress and histopathological changes in rat liver induced by PQ. The results showed that AEE could reduce the hepatotoxicity induced by PQ and . AEE reduced PQ-induced hepatotoxicity by inhibitingoxidative stress and maintaining mitochondrial function. This study proved that AEE is an effective antioxidant and can reduce the hepatotoxicity of PQ.
阿司匹林丁香酚酯（AEE）是一种具有抗炎和抗氧化应激药理活性的新型潜在药物。百草枯（PQ）是一种有效且在商业上重要的除草剂，在全球广泛使用。然而，百草枯具有高毒性，可导致各种并发症和急性器官损伤，如肝、肾和肺损伤。本研究的目的是调查AEE对PQ诱导的肝毒性是否具有保护作用。检测细胞活力、凋亡率、线粒体功能和细胞内氧化应激，以评估AEE对PQ诱导的BRL-3A（正常大鼠肝细胞）细胞毒性的保护作用。AEE预处理可减轻PQ诱导的大鼠肝脏氧化应激和组织病理学变化。结果表明，AEE可降低PQ诱导的肝毒性。AEE通过抑制氧化应激和维持线粒体功能降低PQ诱导的肝毒性。本研究证明AEE是一种有效的抗氧化剂，可降低PQ的肝毒性。
