Lataste P, Soubiran G, Nlend A, Le Bras M, Roue R, Wone C, Ragnaud J C, Buil A, Briand M C, Ripert C
Service de Médecine Interne et Tropicale, Hôpital Saint-André, Bordeaux.
Bull Soc Pathol Exot Filiales. 1987;80(3 Pt 2):561-8.
Five imported falciparum malaria cases with severe evolution are reported. Treatment associated a blood exchange transfusion and an antimalaria chemotherapy (mefloquine in three patients and quinine in two patients). All patients were successfully cured despite of serious visceral complications occurring in two patients (pulmonary and cerebral oedema). Technical management of treatment is detailed. Exchange transfusion should be considered in falciparum malaria when parasitaemia overcomes 20% and when serious visceral impairment, hemolysis or consumption coagulopathy are occurring.
报告了5例输入性恶性疟严重进展病例。治疗采用了换血输血和抗疟疾化疗（3例患者使用甲氟喹，2例患者使用奎宁）。尽管2例患者出现了严重的内脏并发症（肺水肿和脑水肿），但所有患者均成功治愈。详细介绍了治疗的技术管理。当疟原虫血症超过20%且出现严重的内脏损害、溶血或消耗性凝血病时，恶性疟应考虑进行换血输血。
