长链非编码RNA MIR4435-2HG通过miR-22-3p/YWHAZ轴促进肝细胞癌的增殖和转移。
Long noncoding RNA MIR4435-2HG promotes hepatocellular carcinoma proliferation and metastasis through the miR-22-3p/YWHAZ axis.
作者信息
Shen Xuanlin, Ding Yuting, Lu Feng, Yuan Haitao, Luan Wenkang
机构信息
Department of Rehabilitation, Changshu No. 2 People's Hospital (The 5th Clinical Medical College of Yangzhou University) Changshu, Jiangsu, China.
Department of Plastic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu, China.
出版信息
Am J Transl Res. 2020 Oct 15;12(10):6381-6394. eCollection 2020.
Long noncoding RNAs (lncRNAs) play the critical biological role in many malignant tumours. MIR4435-2HG has been proven to be a novel oncogenic lncRNA. However, the exact role and mechanism of MIR4435-2HG in hepatocellular carcinoma (HCC) remain unclear. Here, we found that MIR4435-2HG is overexpressed in HCC tissue compared to normal controls and that high level of MIR4435-2HG indicates a poorer prognosis in HCC patients. MIR4435-2HG enhances the growth and metastasis ability of HCC cells. MIR4435-2HG promotes the expression of YWHAZ by sponging miR-22-3p to liberate YWHAZ mRNA transcripts. MIR4435-2HG facilitates the proliferation and metastasis of HCC by modulating the miR-22-3p/YWHAZ axis. These results demonstrated the role and mechanism of MIR4435-2HG in malignant progression of HCC. MIR4435-2HG may be used as the prognostic marker and treatment target for the patient with HCC.
长链非编码RNA（lncRNAs）在许多恶性肿瘤中发挥着关键的生物学作用。MIR4435-2HG已被证明是一种新型致癌lncRNA。然而，MIR4435-2HG在肝细胞癌（HCC）中的确切作用和机制仍不清楚。在此，我们发现与正常对照相比，MIR4435-2HG在HCC组织中过表达，并且高水平的MIR4435-2HG表明HCC患者预后较差。MIR4435-2HG增强了HCC细胞的生长和转移能力。MIR4435-2HG通过海绵吸附miR-22-3p来释放YWHAZ mRNA转录本，从而促进YWHAZ的表达。MIR4435-2HG通过调节miR-22-3p/YWHAZ轴促进HCC的增殖和转移。这些结果证明了MIR4435-2HG在HCC恶性进展中的作用和机制。MIR4435-2HG可能作为HCC患者的预后标志物和治疗靶点。
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