Chen Zhou, Guan Defeng, Zhu Qiangping, Wang Zhengfeng, Han Fangfang, Zhou Wence
The First Clinical Medical College, Lanzhou University, Lanzhou 730000, China.
The First Hospital of Lanzhou University, Lanzhou 730000, China.
Curr Issues Mol Biol. 2023 Nov 4;45(11):8864-8881. doi: 10.3390/cimb45110556.
The long non-coding RNA MIR4435-2HG has been confirmed to play a crucial regulatory role in various types of tumors. As a novel type of non-coding RNA, MIR4435-2HG plays a key role in regulating the expression of tumor-related genes, interfering with cellular signaling pathways, and affecting tumor immune evasion. Its unique structure allows it to regulate the expression of various tumor-related genes through different pathways, participating in the regulation of tumor signaling pathways, such as regulating the expression of oncogenes and tumor suppressor genes, influencing the biological behaviors of proliferation, metastasis, and apoptosis in tumors. Numerous studies have found a high expression of MIR4435-2HG in various tumor tissues, closely related to the clinical pathological characteristics of tumors, such as staging, lymph node metastasis and prognosis. Some studies have discovered that MIR4435-2HG can regulate the sensitivity of tumor cells to chemotherapy drugs, affecting tumor cell drug resistance. This provides new insights into overcoming tumor drug resistance by regulating MIR4435-2HG. Therefore, studying its molecular mechanisms, expression regulation, and its relationship with the clinical features of tumors is of great significance for revealing the mechanisms of tumor occurrence and developing new therapeutic targets.
长链非编码RNA MIR4435-2HG已被证实在多种类型的肿瘤中发挥关键的调节作用。作为一种新型的非编码RNA，MIR4435-2HG在调节肿瘤相关基因的表达、干扰细胞信号通路以及影响肿瘤免疫逃逸方面发挥着关键作用。其独特的结构使其能够通过不同途径调节多种肿瘤相关基因的表达，参与肿瘤信号通路的调控，如调节癌基因和肿瘤抑制基因的表达，影响肿瘤增殖、转移和凋亡等生物学行为。大量研究发现MIR4435-2HG在多种肿瘤组织中高表达，与肿瘤的临床病理特征如分期、淋巴结转移及预后密切相关。一些研究发现MIR4435-2HG可调节肿瘤细胞对化疗药物的敏感性，影响肿瘤细胞的耐药性。这为通过调节MIR4435-2HG克服肿瘤耐药性提供了新的见解。因此，研究其分子机制、表达调控及其与肿瘤临床特征的关系对于揭示肿瘤发生机制和开发新的治疗靶点具有重要意义。
