Li Kai, Teng Chao, Min Qianhao
Shenzhen Polytechnic, Institute of Marine Biomedicine, Shenzhen, China.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Front Chem. 2020 Oct 23;8:573297. doi: 10.3389/fchem.2020.573297. eCollection 2020.
Epigallocatechin gallate (EGCG) is the most abundant polyphenolic constituent derived from green tea extract, which has demonstrated versatile bioactivities in combating cardiovascular diseases, neurodegenerative diseases, diabetes, and cancer. In light of its anticancer activity, increasing attention has been paid to developing potent strategies involving EGCG in cancer chemotherapy. However, the poor bioavailability and stability of EGCG limits its effectiveness and practicality in real biomedical applications. To overcome this drawback, nanotechnology-facilitated drug delivery systems have been introduced and intensively explored to enhance the bioavailability and therapeutic efficacy of EGCG in cancer treatments and interventions. This review briefly discusses the anticancer mechanisms of EGCG, and then summarizes recent advances in engineering nanovehicles for encapsulating and delivering EGCG toward cancer therapy. In addition, we also highlight successful integrations of EGCG delivery with other chemotherapies, gene therapies, and phototherapies in one nanostructured entity for a combination therapy of cancers. To conclude, the current challenges and future prospects of the nanovehicle-based transportation systems of EGCG for cancer therapy are also discussed.
表没食子儿茶素没食子酸酯（EGCG）是绿茶提取物中含量最丰富的多酚成分，已证明其在对抗心血管疾病、神经退行性疾病、糖尿病和癌症方面具有多种生物活性。鉴于其抗癌活性，人们越来越关注开发在癌症化疗中涉及EGCG的有效策略。然而，EGCG较差的生物利用度和稳定性限制了其在实际生物医学应用中的有效性和实用性。为克服这一缺点，已引入并深入探索了纳米技术辅助的药物递送系统，以提高EGCG在癌症治疗和干预中的生物利用度和治疗效果。本文简要讨论了EGCG的抗癌机制，然后总结了用于封装和递送EGCG以进行癌症治疗的工程纳米载体的最新进展。此外，我们还强调了将EGCG递送与其他化疗、基因治疗和光疗成功整合到一个纳米结构实体中用于癌症联合治疗的情况。最后，还讨论了基于纳米载体的EGCG癌症治疗运输系统当前面临的挑战和未来前景。
