O'Callaghan M W, Hornof W J, Fisher P E, Rabbe O G
Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
Equine Vet J. 1987 Jan;19(1):19-24. doi: 10.1111/j.2042-3306.1987.tb02570.x.
This study describes the development of a radioaerosol technique for horses using 99mtechnetium-DTPA (diethylenetriaminepentacetate). In 24 normal, adult horses, very satisfactory ventilation images were obtained with the technique. Four-minute administrations of the aerosol resulted in a mean uptake of radioactivity in the lung fields of 3.02 mCi, with mean maximum counts (+/- sd) of 159,800 +/- 75,000 per camera field. The mean clearance half-time for the 99mtechnetium-DTPA from the lung fields was 55.6 +/- 14.2 mins which is very similar to figures obtained for normal human and dog lungs. The results of this study suggest that ventilation imaging with 99mtechnetium-DTPA is a clinically practical method of obtaining regional information on ventilation function in the horse.
本研究描述了一种使用锝-99m二乙三胺五乙酸（DTPA）的马匹放射性气溶胶技术的开发。在24匹正常成年马中，该技术获得了非常令人满意的通气图像。气溶胶4分钟给药后，肺野放射性的平均摄取量为3.02毫居里，每个相机视野的平均最大计数（±标准差）为159,800±75,000。锝-99m-DTPA从肺野清除的平均半衰期为55.6±14.2分钟，这与正常人和犬肺的数值非常相似。本研究结果表明，用锝-99m-DTPA进行通气成像，是一种在临床上获取马匹通气功能区域信息的实用方法。
