羽衣甘蓝对人体测量学指标的影响：临床试验的系统评价和剂量反应荟萃分析。
The effects of supplementation with Cynara scolymus L. on anthropometric indices: А systematic review and dose-response meta-analysis of clinical trials.
机构信息
Internal Medicine Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
School of Nutrition, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung City, Taiwan, ROC.
出版信息
Complement Ther Med. 2021 Jan;56:102612. doi: 10.1016/j.ctim.2020.102612. Epub 2020 Nov 7.
BACKGROUND
Studies on the efficacy of artichoke administration on anthropometric indices gave different outcomes. Hence, a systematic review and dose-response meta-analysis were accomplished to understand the effects of artichoke administration on anthropometric indices.
METHODS
Related clinical trials were found by searching in PubMed, Embase, the Cochrane Library and Scopus databases up to 29 February 2020. Weighted Mean Differences (WMD) were analyzed using a random-effects model. Heterogeneity, publication bias and sensitivity analysis were assessed for anthropometric indices.
RESULTS
Pooled analysis of 10 randomized controlled trials (RCTs) suggested that the artichoke administration has effect on waist circumference (WMD: -1.11 cm, 95 % CI: -2.08 to - 0.14), as opposed to the other anthropometric indices including weight (WMD: -0.62 kg, 95 % CI: -1.86 to 0.61) or BMI (WMD: -0.12, 95 % CI: -0.43 to 0.20). However, the analysis of the subgroups according to the health status showed that artichoke supplementation in hypertensive patients significantly reduced weight (WMD: -2.34 kg, 95 % CI: -3.11 to -1.57) but not the other indicators (WMD: -0.06 kg, 95 % CI: 0.78 to 0.67).
CONCLUSIONS
The artichoke supplementation has effect on the waist circumference, but not on the other anthropometric indices. For establishment of more accurate conclusion more studies with longer administration duration are need to be done.
背景
关于洋蓟制剂对人体测量学指标疗效的研究结果不尽相同。因此，我们进行了系统评价和剂量-反应荟萃分析，以了解洋蓟制剂对人体测量学指标的影响。
方法
通过检索 PubMed、Embase、Cochrane 图书馆和 Scopus 数据库，我们于 2020 年 2 月 29 日查找了相关的临床试验。使用随机效应模型分析加权均数差（WMD）。对人体测量学指标进行异质性、发表偏倚和敏感性分析。
结果
对 10 项随机对照试验（RCT）的汇总分析表明，洋蓟制剂对腰围（WMD：-1.11cm，95%CI：-2.08 至-0.14）有影响，但对其他人体测量学指标（体重：WMD：-0.62kg，95%CI：-1.86 至 0.61）或 BMI（WMD：-0.12，95%CI：-0.43 至 0.20）没有影响。然而，根据健康状况进行的亚组分析显示，洋蓟补充剂可显著降低高血压患者的体重（WMD：-2.34kg，95%CI：-3.11 至-1.57），但对其他指标无影响（WMD：-0.06kg，95%CI：0.78 至 0.67）。
结论
洋蓟补充剂对腰围有影响，但对其他人体测量学指标无影响。为了得出更准确的结论，需要进行更多具有更长给药时间的研究。
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