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利用蛋白质-蛋白质相互作用网络分析连接 SARS-CoV-2 的垂直传播 - 胎盘 ACE2 和 ENDOU 的潜在作用。

Connecting the dots on vertical transmission of SARS-CoV-2 using protein-protein interaction network analysis - Potential roles of placental ACE2 and ENDOU.

机构信息

Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, IL, 60612, USA.

Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, IL, 60612, USA.

出版信息

Placenta. 2021 Jan 15;104:16-19. doi: 10.1016/j.placenta.2020.11.001. Epub 2020 Nov 9.

DOI:10.1016/j.placenta.2020.11.001
PMID:33197855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7649632/
Abstract

We conducted a protein-protein interaction (PPI) network study searching for proteins relevant to pregnancy-associated COVID-19 in pregnancy complicated with severe preeclampsia (sPE) and intra-amniotic infection and/or inflammation (Triple-I). PPI networks from sPE and Triple-I were intersected with the PPI network from coronavirus infection. Common proteins included the SARS-CoV-2 entry receptor ACE2 and ENDOU, a placental endoribonuclease homologous to Nsp15, a protein produced by the virus to escape host immunity. Remarkably, placental ENDOU mRNA expression far exceeded that of ACE2. Immunohistochemistry confirmed ENDOU localization at the hemochorial maternal-fetal interface. Investigation of ENDOU's relevance to vertical transmission of SARS-CoV-2 is further warranted.

摘要

我们进行了蛋白质-蛋白质相互作用（PPI）网络研究，寻找与妊娠合并严重子痫前期（sPE）和羊膜内感染和/或炎症（Triple-I）相关的蛋白质。sPE 和 Triple-I 的 PPI 网络与冠状病毒感染的 PPI 网络相交。共同的蛋白质包括 SARS-CoV-2 进入受体 ACE2 和 ENDOU，一种与 Nsp15 同源的胎盘内切核酸酶，是病毒产生的一种逃避宿主免疫的蛋白质。值得注意的是，胎盘 ENDOU mRNA 的表达远远超过 ACE2。免疫组织化学证实了 ENDOU 在合胞体母体-胎儿界面的定位。进一步研究 ENDOU 与 SARS-CoV-2 垂直传播的相关性是有必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a6/7649632/c39d0e06f0eb/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a6/7649632/9eebf9c1b4ec/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a6/7649632/c39d0e06f0eb/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a6/7649632/9eebf9c1b4ec/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47a6/7649632/c39d0e06f0eb/gr2_lrg.jpg

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