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母体严重急性呼吸综合征冠状病毒 2 感染中胎盘 ACE2 和 TMPRSS2 的表达：胎盘防御是否受胎儿性别影响？

Placental Expression of ACE2 and TMPRSS2 in Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Are Placental Defenses Mediated by Fetal Sex?

机构信息

Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

出版信息

J Infect Dis. 2021 Dec 8;224(Suppl 6):S647-S659. doi: 10.1093/infdis/jiab335.

DOI:10.1093/infdis/jiab335
PMID:34293137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8344531/
Abstract

BACKGROUND

Expression of angiotensin-converting enzyme 2 (ACE2) and type II transmembrane serine protease (TMPRSS2), host molecules required for viral entry, may underlie sex differences in vulnerability to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated whether placental ACE2 and TMPRSS2 expression vary by fetal sex in the presence of maternal SARS-CoV-2 infection.

METHODS

Placental ACE2 and TMPRSS2 expression was quantified by quantitative reverse transcription polymerase chain reaction (RT-PCR) and by Western blot in 68 pregnant women (38 SARS-CoV-2 positive, 30 SARS-CoV-2 negative) delivering at Mass General Brigham from April to June 2020. The impact of fetal sex and maternal SARS-CoV-2 exposure on ACE2 and TMPRSS2 was analyzed by 2-way analysis of variance (ANOVA).

RESULTS

Maternal SARS-CoV-2 infection impacted placental TMPRSS2 expression in a sexually dimorphic fashion (2-way ANOVA interaction, P = .002). We observed no impact of fetal sex or maternal SARS-CoV-2 status on ACE2. TMPRSS2 expression was significantly correlated with ACE2 expression in males (Spearman ρ = 0.54, P = .02) but not females (ρ = 0.23, P = .34) exposed to maternal SARS-CoV-2.

CONCLUSIONS

Sex differences in placental TMPRSS2 but not ACE2 were observed in the setting of maternal SARS-CoV-2 infection, which may have implications for offspring vulnerability to placental infection.

摘要

背景

血管紧张素转换酶 2（ACE2）和 II 型跨膜丝氨酸蛋白酶（TMPRSS2）的表达，即病毒进入宿主所需的分子，可能是导致严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染易感性存在性别差异的基础。我们研究了母体 SARS-CoV-2 感染时，胎儿性别是否会影响胎盘 ACE2 和 TMPRSS2 的表达。

方法

在 2020 年 4 月至 6 月期间，在马萨诸塞州综合医院分娩的 68 名孕妇（38 名 SARS-CoV-2 阳性，30 名 SARS-CoV-2 阴性）中，通过定量逆转录聚合酶链反应（RT-PCR）和 Western blot 定量检测胎盘 ACE2 和 TMPRSS2 的表达。通过双因素方差分析（ANOVA）分析胎儿性别和母体 SARS-CoV-2 暴露对 ACE2 和 TMPRSS2 的影响。

结果

母体 SARS-CoV-2 感染以性别二态的方式影响胎盘 TMPRSS2 的表达（双因素 ANOVA 交互作用，P =.002）。我们没有观察到胎儿性别或母体 SARS-CoV-2 状态对 ACE2 的影响。TMPRSS2 的表达与暴露于母体 SARS-CoV-2 的男性（Spearman ρ = 0.54，P =.02）而非女性（ρ = 0.23，P =.34）的 ACE2 显著相关。

结论

在母体 SARS-CoV-2 感染的情况下，胎盘 TMPRSS2 而非 ACE2 存在性别差异，这可能对后代胎盘感染的易感性有影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/872d74b4270f/jiab335f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/3bc3676ff100/jiab335f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/7e4be89f3b20/jiab335f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/872d74b4270f/jiab335f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/3bc3676ff100/jiab335f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/7e4be89f3b20/jiab335f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abe/8656297/872d74b4270f/jiab335f0003.jpg

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