Jiao Yu Yang, Okada Masahiro, Hara Emilio Satoshi, Xie Shi Chao, Nagaoka Noriyuki, Nakano Takayoshi, Matsumoto Takuya
Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Materials (Basel). 2020 Nov 12;13(22):5099. doi: 10.3390/ma13225099.
Despite the fact that various reports have been discussing bone tissue regeneration, precise bone tissue manipulation, such as controlling the physical properties of the regenerated bone tissue, still remains a big challenge. Here, we focused on the teleost fish ribs showing flexible and tough mechanical properties to obtain a deeper insight into the structural and functional features of bone tissue from different species, which would be valuable for the superior design of bone-mimicking materials. Herein, we examined their compositions, microstructure, histology, and mechanical properties. The first rib of Carassius langsdorfii showed a higher Young's modulus with a small region of chondrocyte clusters compared with other smaller ribs. In addition, highly oriented collagen fibers and osteocytes were observed in the first rib, indicating that the longest first rib would be more mature. Moreover, the layer-by-layer structure of the oriented bone collagen was observed in each rib. These microarchitectural and compositional findings of fish rib bone would give one the useful idea to reproduce such a highly flexible rib bone-like material.
尽管已有各种报道讨论骨组织再生，但精确控制骨组织，如控制再生骨组织的物理特性，仍然是一个巨大的挑战。在此，我们聚焦于具有柔韧且坚韧机械性能的硬骨鱼肋骨，以更深入了解不同物种骨组织的结构和功能特征，这对于仿生骨材料的优化设计具有重要价值。在此，我们研究了它们的组成、微观结构、组织学和机械性能。与其他较小的肋骨相比，兰氏鲫的第一肋骨显示出更高的杨氏模量，且软骨细胞簇区域较小。此外，在第一肋骨中观察到高度定向的胶原纤维和骨细胞，表明最长的第一肋骨更成熟。而且，在每根肋骨中都观察到了定向骨胶原的层状结构。鱼肋骨的这些微观结构和组成方面的发现将为人们提供有用的思路，以重现这种高度柔韧的肋骨状材料。
