Jiao YuYang, Okada Masahiro, Nutan Bhingaradiya, Nagaoka Noriyuki, Bikharudin Ahmad, Musa Randa, Matsumoto Takuya
Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Advanced Research Center for Oral and Craniofacial Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan.
Polymers (Basel). 2023 Oct 23;15(20):4190. doi: 10.3390/polym15204190.
Biological materials have properties like great strength and flexibility that are not present in synthetic materials. Using the ribs of crucian carp as a reference, we investigated the mechanisms behind the high mechanical properties of this rib bone, and found highly oriented layers of calcium phosphate (CaP) and collagen fibers. To fabricate a fish-rib-bone-mimicking membrane with similar structure and mechanical properties, this study involves (1) the rapid synthesis of plate-like CaP crystals, (2) the layering of CaP-gelatin hydrogels by gradual drying, and (3) controlling the shape of composite membranes using porous gypsum molds. Finally, as a result of optimizing the compositional ratio of CaP filler and gelatin hydrogel, a CaP filler content of 40% provided the optimal mechanical properties of toughness and stiffness similar to fish bone. Due to the rigidity, flexibility, and ease of shape control of the composite membrane materials, this membrane could be applied as a guided bone regeneration (GBR) membrane.
生物材料具有合成材料所没有的高强度和柔韧性等特性。以鲫鱼的肋骨为参考，我们研究了这种肋骨骨具有高机械性能的背后机制，发现了高度取向的磷酸钙（CaP）层和胶原纤维。为了制造具有类似结构和机械性能的仿鱼肋骨膜，本研究涉及：（1）快速合成板状CaP晶体；（2）通过逐步干燥使CaP - 明胶水凝胶分层；（3）使用多孔石膏模具控制复合膜的形状。最后，通过优化CaP填料和明胶水凝胶的组成比例，40%的CaP填料含量提供了与鱼骨相似的最佳韧性和刚度机械性能。由于复合膜材料的刚性、柔韧性和易于形状控制，这种膜可作为引导骨再生（GBR）膜应用。
