Zeng Jian-Hua, Liu Shi-Wei, Xiong Long, Qiu Peng, Ding Ling-Hua, Xiong Shi-Lang, Li Jing-Tang, Liao Xin-Gen, Tang Zhi-Ming
Department of Orthopaedics, Jiangxi People's Hospital, No.152, Ai guo Road, Nanchang, 330006, China.
Department of Orthopaedics, Jiangxi medical college, Nanchang university, Nanchang, China.
J Orthop Surg Res. 2018 Feb 12;13(1):33. doi: 10.1186/s13018-018-0724-2.
This systematic review aims to summarize the clinical studies on the use of scaffolds in the repair of bony defects.
The relevant articles were searched through PubMed database. The following keywords and search terms were used: "scaffolds," "patient," "clinic," "bone repair," "bone regeneration," "repairing bone defect," "repair of bone," "osteanagenesis," "osteanaphysis," and "osteoanagenesis." The articles were screened according to inclusion and exclusion criteria, performed by two reviewers.
A total of 373 articles were obtained using PubMed database. After screening, 20 articles were identified as relevant for the purpose of this systematic review. We collected the data of biological scaffolds and synthetic scaffolds. There are eight clinical studies of biological scaffolds included collagen, gelatin, and cellular scaffolds for bone healing. In addition, 12 clinical studies of synthetic scaffolds on HAp, TCP, bonelike, and their complex scaffolds for repairing bone defects were involved in this systematic review.
There are a lot of clinical evidences showed that application of scaffolds had a good ability to facilitate bone repair and osteogenesis. However, the ideal and reliable guidelines are insufficiently applied and the number and quality of studies in this field remain to be improved.
本系统评价旨在总结关于使用支架修复骨缺损的临床研究。
通过PubMed数据库检索相关文章。使用了以下关键词和检索词：“支架”“患者”“临床”“骨修复”“骨再生”“修复骨缺损”“骨修复”“骨生成”“骨愈合”和“骨再生”。由两名 reviewers 根据纳入和排除标准筛选文章。
使用PubMed数据库共获得373篇文章。筛选后，确定20篇文章与本系统评价的目的相关。我们收集了生物支架和合成支架的数据。有八项关于生物支架的临床研究，包括用于骨愈合的胶原蛋白、明胶和细胞支架。此外，本系统评价还涉及12项关于合成支架（如羟基磷灰石、磷酸三钙、骨样支架及其复合支架）修复骨缺损的临床研究。
有许多临床证据表明，应用支架具有促进骨修复和成骨的良好能力。然而，理想且可靠的指南应用不足，该领域的研究数量和质量仍有待提高。
