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本月课程:被遗忘的经典:以奥尔特纳综合征为首发表现的二尖瓣狭窄的延迟诊断。

Lessons of the month: A forgotten classic: Delayed diagnosis of mitral stenosis presenting initially as Ortner's syndrome.

机构信息

Universiti Teknologi MARA, Sungai Buloh, Malaysia

Universiti Teknologi MARA, Sungai Buloh, Malaysia.

出版信息

Clin Med (Lond). 2020 Nov;20(6):e267-e268. doi: 10.7861/clinmed.2020-0750.

Abstract

We present a rare case of delayed diagnosis of mitral stenosis, initially presenting with hoarseness in her voice due to left recurrent laryngeal nerve (LRLN) compression. A 60-year-old woman presented to the otorhinolaryngology department following complaints of progressive hoarseness in voice over a 6-month period. There was dysphonia but no additional evidence of a cranial nerve IX or X palsy on examination, with subsequent flexible nasopharyngolaryngoscopy demonstrating left vocal cord palsy. She was referred for a cardiology consult following findings of atrial fibrillation on electrocardiography. Transthoracic echocardiography revealed an enlarged left atrium with evidence of severe mitral stenosis. A diagnosis of Ortner's syndrome was made and the patient underwent mitral valve replacement. Common causes of Ortner's syndrome include mitral stenosis with left atrium compression of the LRLN, but it can occur due to other causes including pulmonary hypertension or aortic aneurysm compression, among others. There are few data at present to conclude that regression of left atrial enlargement and pulmonary arterial hypertension with symptoms are associated with Ortner's syndrome. Therefore, it remains pertinent for clinicians to be aware of clinical features linked to mitral stenosis including its more uncommon presentations, such as in our case, as earlier intervention may improve prognosis.

摘要

我们呈现了一例罕见的二尖瓣狭窄延迟诊断病例,最初表现为左侧喉返神经(LRLN)受压导致声音嘶哑。一位 60 岁女性因声音进行性嘶哑 6 个月就诊耳鼻喉科。检查时仅发现声嘶,无其他颅神经 IX 或 X 麻痹的证据,随后行软性鼻咽纤维喉镜检查显示左侧声带麻痹。心电图发现心房颤动后,她被转介至心内科就诊。经胸超声心动图显示左心房增大,有严重二尖瓣狭窄的证据。诊断为奥尔特纳综合征,患者接受了二尖瓣置换术。奥尔特纳综合征的常见病因包括左心房受压引起的二尖瓣狭窄和 LRLN,但其也可由其他原因引起,包括肺动脉高压或主动脉瘤压迫等。目前尚无足够数据得出结论,认为左心房扩大和肺动脉高压的症状消退与奥尔特纳综合征有关。因此,临床医生仍需要了解与二尖瓣狭窄相关的临床特征,包括其更不常见的表现,如本病例,因为早期干预可能改善预后。

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本文引用的文献

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Ortner's syndrome: case series and literature review.奥尔特纳综合征:病例系列及文献回顾。
Braz J Otorhinolaryngol. 2011 Sep-Oct;77(5):559-62. doi: 10.1590/s1808-86942011000500004.
3
Mitral stenosis.二尖瓣狭窄
Lancet. 2009 Oct 10;374(9697):1271-83. doi: 10.1016/S0140-6736(09)60994-6. Epub 2009 Sep 9.
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Ortner's syndrome and endoluminal treatment of a thoracic aortic aneurysm: a case report.
Vasc Endovascular Surg. 2006 Jan-Feb;40(1):75-8. doi: 10.1177/153857440604000111.
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Ortner syndrome and haemophilia.奥尔特纳综合征与血友病。
Haemophilia. 2005 Sep;11(5):548-51. doi: 10.1111/j.1365-2516.2005.01140.x.

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