Hecker Andrzej, Watzinger Nikolaus, Pignet Anna-Lisa, Michelitsch Birgit, Kotzbeck Petra, Kamolz Lars-Peter
Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Auenbruggerplatz 29/4, 8036 Graz, Austria.
COREMED-Centre for Regenerative Medicine and Precision Medicine, Joanneum Research Forschungsgesellschaft mbH, Neue Stiftingtalstraße 2, 8010 Graz, Austria.
J Pers Med. 2024 May 8;14(5):498. doi: 10.3390/jpm14050498.
A new ceramic dressing, free from active antimicrobial or pharmaceutical agents, uses physical binding mechanisms for its absorption capacities and bacterial-binding properties. The purpose of this study was to evaluate wound healing, bacterial-related retention, and diagnostic properties of ceramic dressings in patients with stagnated chronic wounds.
In this monocentric, intra-individually controlled, prospective study, patients with conservatively treated refractory chronic wounds were enrolled. One week before the start of the application with ceramic dressing, it was ensured during a screening phase that chronic wounds showed less than a 10% reduction in wound size. During the 4-week ceramic dressing treatment wound size measurements, wound scoring, measurement of wound exudate amount, wound swabs, and ceramic dressing sonication (low-intensity ultrasound) were carried out. The sonication fluid of the removed ceramic dressing was used for analysis of bacterial retention and compared to wound swabs.
A total of 20 patients with a mean age of 64.6 years (±26.2) and 21 chronic wounds were included in this study. After a 4-week treatment, a significant reduction of median wound size from 1178 mm (range 104-6300) to 751.5 mm (range 16-4819) and better total wound scores were observed ( < 0.001). The sensitivity of bacteria detection was 90.7% in the sonication fluid from the ceramic dressings, while only 76.9% in the conventional wound swabs.
The new ceramic dressing seems to have a positive impact on wound healing in chronic wounds. Bacteria-binding characteristics of the investigated ceramic dressing, in combination with its debridement, absorption, and detoxification properties, could contribute to its healing abilities. Based on those results, the investigated ceramic dressing seems to be a promising new treatment option for chronic wounds without the use of any active antimicrobial or pharmacological agents. Moreover, ceramic dressings can also be considered for microbiological diagnostic purposes.
一种新型陶瓷敷料，不含活性抗菌剂或药物成分，利用物理结合机制实现其吸收能力和细菌结合特性。本研究的目的是评估陶瓷敷料对慢性伤口停滞患者伤口愈合、细菌相关滞留及诊断特性的影响。
在这项单中心、个体内对照、前瞻性研究中，纳入了接受保守治疗的难治性慢性伤口患者。在开始使用陶瓷敷料前一周，在筛查阶段确保慢性伤口的伤口大小减少不到10%。在为期4周的陶瓷敷料治疗期间，进行伤口大小测量、伤口评分、伤口渗出液量测量、伤口拭子采集以及陶瓷敷料超声处理（低强度超声）。取出的陶瓷敷料的超声处理液用于分析细菌滞留情况，并与伤口拭子进行比较。
本研究共纳入20例平均年龄为64.6岁（±26.2）的患者和21处慢性伤口。经过4周治疗，观察到伤口中位数大小从1178毫米（范围104 - 6300）显著减少至751.5毫米（范围16 - 4819），且总伤口评分更佳（<0.001）。陶瓷敷料超声处理液中细菌检测的灵敏度为90.7%，而传统伤口拭子中仅为76.9%。
新型陶瓷敷料似乎对慢性伤口的愈合有积极影响。所研究的陶瓷敷料的细菌结合特性，及其清创、吸收和解毒特性，可能有助于其愈合能力。基于这些结果，所研究的陶瓷敷料似乎是一种有前景的慢性伤口新治疗选择，无需使用任何活性抗菌剂或药物。此外，陶瓷敷料也可用于微生物诊断目的。
