Department of Epidemiology and Biostatistics, Faculty of Public Health, Lebanese University, Fanar, Lebanon.
INSPECT-LB, National Institute of Public Health, Clinical Epidemiology and Toxicology-Liban, Beirut, Lebanon.
Int J Clin Pharm. 2021 Aug;43(4):918-927. doi: 10.1007/s11096-020-01197-9. Epub 2020 Nov 17.
Background Adherence to oral antidiabetics plays a pivotal role in controlling diabetes. Healthcare workers evaluate this adherence when visited by patients. Objectives The primary objective of this study was to validate the existing LMAS-14 (Lebanese Medication Adherence Scale) in Lebanese diabetic adults. The secondary objective was to evaluate factors affecting adherence among this population. Setting The main five Lebanese governorates. Methods This study was conducted between May and September 2019, and community dwelling adult participants were enrolled using a proportionate random sample. The scale was validated using factor analysis and reliability testing, while bivariate and multivariable analyses assessed correlates of adherence. Main outcomes measures Validity of LMAS-14. Results A total of 308 participants were included, and the response rate was 91.25%. All LMAS-14 items converged over a solution of four factors, explaining a total of 64.39% of the variance (α = 0.859). The cutoff point between controlled and uncontrolled patients was set at 11. The sensitivity and specificity were good at this cutoff (71.1% and 94.74%, respectively). Results showed that 167 (57.2%) patients had good medication adherence. Advanced age (Beta = 0.046; p = 0.001) and having medical coverage (Beta = 1.452; p = 0.005) were significantly associated with higher adherence. Furthermore, adherence to oral antidiabetic drugs (Beta = 1.197; p = 0.018), female gender (Beta = 2.695; p = 0.011), and taking dyslipidemia medication (Beta = 3.527; p = 0.005) predicted higher diabetes control. Conclusion This study validated the LMAS among Lebanese adult diabetic patients taking oral antidiabetic drug. Advanced age and having medical coverage were associated with higher medication adherence. Further national studies are warranted to corroborate our findings.
口服抗糖尿病药物的依从性对于控制糖尿病起着关键作用。当患者就诊时,医护人员会评估这种依从性。
本研究的主要目的是验证黎巴嫩成年糖尿病患者中现有的 LMAS-14(黎巴嫩药物依从性量表)。次要目的是评估该人群中影响依从性的因素。
黎巴嫩五个主要省份。
这项研究于 2019 年 5 月至 9 月进行,使用比例随机抽样的方法招募社区居住的成年参与者。使用因子分析和可靠性测试验证量表的有效性,同时进行双变量和多变量分析评估依从性的相关因素。
LMAS-14 的有效性。
共纳入 308 名参与者,应答率为 91.25%。所有 LMAS-14 项目均集中在四个因素的解决方案上,共解释了 64.39%的方差(α=0.859)。将控制和未控制患者的切点设定为 11。在这个截点处,敏感性和特异性都很好(分别为 71.1%和 94.74%)。结果显示,167 名(57.2%)患者具有良好的药物依从性。年龄较大(β=0.046;p=0.001)和有医疗保险(β=1.452;p=0.005)与更高的依从性显著相关。此外,口服抗糖尿病药物的依从性(β=1.197;p=0.018)、女性(β=2.695;p=0.011)和服用血脂调节药物(β=3.527;p=0.005)均预测糖尿病控制更好。
本研究验证了黎巴嫩成年糖尿病患者口服抗糖尿病药物使用的 LMAS。年龄较大和有医疗保险与更高的药物依从性相关。需要进一步进行全国性研究来证实我们的发现。