Faculty of Health and Social Sciences, University of South Bohemia, Ceske Budejovice, Czech Republic.
Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine, AS CR, Prague, Czech Republic.
Neuro Endocrinol Lett. 2020 Sep;41(3):146-153.
Air pollution in ambient air could affect the increase of obesity in children.
Review analyze papers about the effect of polycyclic aromatic hydrocarbons (PAHs), fine particles (particulate matter < 2.5 μm, PM2.5), and traffic air pollution (NO2, NOx, PM2.5).
Prenatal exposure to concentrations 1.73-3.07 ng/m3 PAHs significantly increased obesity at age 5 and 7 years, up to 11 years. All studies indicate the significance of prenatal exposure with concentration > 0.3 ng/m3 of B[a]P (benzo[a]pyrene). Prenatal exposure to PM2.5 above concentrations 10.6-11.9 μg/m3 increased obesity in children up to the age of 9 years. Traffic air pollution was evaluated according to exposure to NO2 and PM2.5. Concentrations NO2 higher 30 μg/m3 affect adiponectin levels in cord blood, cholesterol metabolism, and therefore increase later the risk of overweight or obesity. PM2.5 9.2-11.6 μg/m3 during pregnancy affect adiponectin. These concentrations from the traffic air pollution can affect the metabolism in newborns later related to obesity.
All these studies indicate that contemporary concentrations of PAHs, PM2.5 and NO2 in ambient air, especially during prenatal period, affect overweight and obesity in children.
环境空气中的空气污染可能会影响儿童肥胖的增加。
综述分析有关多环芳烃(PAHs)、细颗粒物(<2.5μm 的颗粒物,PM2.5)和交通空气污染(NO2、NOx、PM2.5)对肥胖影响的研究论文。
产前暴露于浓度为 1.73-3.07ng/m3 的 PAHs 可显著增加 5 岁和 7 岁时的肥胖症,甚至到 11 岁时仍然如此。所有研究均表明,浓度>0.3ng/m3 的 B[a]P(苯并[a]芘)的产前暴露具有重要意义。产前暴露于 PM2.5 浓度高于 10.6-11.9μg/m3 会增加儿童 9 岁时的肥胖风险。交通空气污染是根据 NO2 和 PM2.5 的暴露情况来评估的。浓度高于 30μg/m3 的 NO2 会影响脐血中的脂联素水平、胆固醇代谢,从而增加超重或肥胖的风险。怀孕期间 PM2.5 为 9.2-11.6μg/m3 会影响脂联素。这些来自交通空气污染的浓度会影响新生儿以后与肥胖相关的代谢。
所有这些研究都表明,环境空气中当前的 PAHs、PM2.5 和 NO2 浓度,尤其是在产前期间,会影响儿童超重和肥胖。