Alderete T L, Song A Y, Bastain T, Habre R, Toledo-Corral C M, Salam M T, Lurmann F, Gilliland F D, Breton C V
Department of Preventive Medicine, Division of Environmental Health, University of Southern California, Los Angeles, USA.
Department of Public Health, California State University Los Angeles, Los Angeles, USA.
Pediatr Obes. 2018 Jun;13(6):348-356. doi: 10.1111/ijpo.12248. Epub 2017 Nov 3.
Studies suggest that prenatal exposure to traffic-related air pollution (TRAP) may contribute to childhood obesity. While exact mechanisms for this association are unknown, circulating adipokines are hypothesized to contribute to early-life weight gain.
The Maternal and Child Health Study birth cohort included 136 women from the Los Angeles County + University of Southern California Medical Center. This study estimated prenatal residential TRAP exposure and used linear regression analysis to examine associations between adipokines with TRAP exposure and infant weight change (birth to 6 months).
A one standard deviation (1-SD: 2 ppb) increase in prenatal non-freeway nitrogen oxides was associated with 33% (P = 0.01) higher leptin and 9% higher high molecular weight adiponectin levels (P = 0.07) in cord blood. Leptin levels were 71% higher in mothers who lived <75 m than those living >300 m from major roadways (P = 0.03). A 1-SD (10 ng mL ) increase in leptin was associated with a significant increase in infant weight change in female infants (0.62 kg, P = 0.02) but not male infants (0.11 kg, P = 0.48).
Higher TRAP exposures were associated with higher cord blood levels of leptin and high molecular weight adiponectin. These adipokines were associated with increased infant weight change in female infants, which may have implications for future obesity risk.
研究表明，产前暴露于交通相关空气污染（TRAP）可能导致儿童肥胖。虽然这种关联的确切机制尚不清楚，但推测循环中的脂肪因子可能导致早期体重增加。
母婴健康研究出生队列包括来自洛杉矶县+南加州大学医学中心的136名女性。本研究估计了产前居住环境中的TRAP暴露情况，并使用线性回归分析来检验脂肪因子与TRAP暴露以及婴儿体重变化（出生至6个月）之间的关联。
产前非高速公路氮氧化物每增加一个标准差（1-SD：2 ppb），脐带血中的瘦素水平升高33%（P = 0.01），高分子量脂联素水平升高9%（P = 0.07）。居住在距离主要道路小于75米的母亲的瘦素水平比居住在距离主要道路大于300米的母亲高71%（P = 0.03）。瘦素每增加1-SD（10 ng/mL），女婴的婴儿体重变化显著增加（0.62 kg，P = 0.02），而男婴则无显著变化（0.11 kg，P = 0.48）。
较高的TRAP暴露与脐带血中较高的瘦素和高分子量脂联素水平相关。这些脂肪因子与女婴婴儿体重变化增加有关，这可能对未来的肥胖风险产生影响。
