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家庭空气污染暴露与老年人常见慢性病的生态学研究。

Ecological study on household air pollution exposure and prevalent chronic disease in the elderly.

机构信息

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Student's Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Sci Rep. 2023 Jul 20;13(1):11763. doi: 10.1038/s41598-023-39059-9.

Abstract

Older people spend most of their time indoors. Limited evidence demonstrates that exposure to indoor air pollutants might be related to chronic complications. This study aimed to estimate the correlation between household air pollution (HAP)'s long-term exposure and the prevalence of elevated hypertension, diabetes mellitus (DM), obesity, and low-density lipoprotein (LDL) cholesterol. From the Global Burden disease dataset, we extracted HAP, hypertension, DM, body mass index, and LDL cholesterol data from Iran from 1990 to 2019 to males and females in people over 50 years. We present APC and AAPC and their confidence intervals using Joinpoint Software statistical software. R software examined the correlation between HAP and hypertension, DM2, Obesity, and high LDL cholesterol. Our finding showed a significant and positive correlation between HAP exposure and prevalence of high low-density lipoprotein cholesterol (p ≤ 0.001, r = 0.70), high systolic blood pressure (p ≤ 0.001, r = 0.63), and high body mass index (p ≤ 0.001, r = 0.57), and DM2 (p ≤ 0.001, r = 0.38). The analysis results also illustrated a positive correlation between indoor air pollution and smoking (p ≤ 0.001, r = 0.92). HAP exposure might be a risk factor for elevated blood pressure, DM, obesity, and LDL cholesterol and, consequently, more serious health problems. According to our results, smoking is one of the sources of HAP. However, ecological studies cannot fully support causal relationships, and this article deals only with Iran. Our findings should be corroborated in personal exposure and biomonitoring approach studies.

摘要

老年人大部分时间都在室内度过。有限的证据表明,室内空气污染物的暴露可能与慢性并发症有关。本研究旨在估计家庭空气污染(HAP)的长期暴露与高血压、糖尿病(DM)、肥胖和低密度脂蛋白(LDL)胆固醇升高的患病率之间的相关性。我们从全球疾病负担数据集提取了伊朗 1990 年至 2019 年 50 岁以上男性和女性的 HAP、高血压、DM、体重指数和 LDL 胆固醇数据。我们使用 Joinpoint 软件统计软件呈现 APC 和 AAPC 及其置信区间。R 软件检查了 HAP 与高血压、DM2、肥胖和高 LDL 胆固醇之间的相关性。我们的研究结果表明,HAP 暴露与高 LDL 胆固醇(p≤0.001,r=0.70)、高收缩压(p≤0.001,r=0.63)和高体重指数(p≤0.001,r=0.57)和 DM2(p≤0.001,r=0.38)的患病率之间存在显著正相关。分析结果还表明,室内空气污染与吸烟之间存在正相关(p≤0.001,r=0.92)。HAP 暴露可能是血压升高、DM、肥胖和 LDL 胆固醇升高以及更严重健康问题的危险因素。根据我们的研究结果,吸烟是 HAP 的来源之一。然而,生态研究不能充分支持因果关系,本文仅涉及伊朗。我们的研究结果应在个人暴露和生物监测方法研究中得到证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8035/10359274/954193ffe192/41598_2023_39059_Fig1_HTML.jpg

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