Department of Pathology and Clinical Laboratory, Kansai Medical University, Osaka, Japan.
Department of Surgery, Kansai Medical University, Osaka, Japan.
PLoS One. 2020 Nov 17;15(11):e0242563. doi: 10.1371/journal.pone.0242563. eCollection 2020.
Adipophilin is a lipid droplet-associated protein whose expression can act as a prognostic marker for specific cancers. Using immunohistochemical staining and tissue microarrays, we assayed the expression of adipophilin in 61 patients with triple-negative breast cancer (TNBC) who underwent surgery from January 2006-December 2018. Relapse-free survival (RFS) and its risk factors were analyzed based on adipophilin expression. Fourteen (23.0%) patients expressed adipophilin. As compared to the adipophilin-negative TNBC patients, adipophilin-positive patients exhibited poor RFS (p = 0.032). Among the TNBC patients with a high Ki-67 labeling index, patients negative for adipophilin exhibited better RFS than patients positive for adipophilin (p = 0.032). Moreover, among patients who did not undergo adjuvant chemotherapy, patients negative for adipophilin expression exhibited better RFS than adipophilin-positive patients (p = 0.080). Multivariate analysis showed that adipophilin expression correlated with a high rate of relapse (hazard ratio, 4.89; 95% confidence interval, 1.04-23.0; p = 0.044). Taken together, these results indicate that adipophilin is a novel marker for the poor prognosis of patients with TNBC.
脂滴相关蛋白脂肪因子在特定癌症中可以作为一种预后标志物。本研究使用免疫组织化学染色和组织微阵列分析，检测了 61 例 2006 年 1 月至 2018 年 12 月接受手术的三阴性乳腺癌（TNBC）患者中脂肪因子的表达。根据脂肪因子的表达情况分析无复发生存率（RFS）及其危险因素。有 14 例（23.0%）患者表达脂肪因子。与脂肪因子阴性的 TNBC 患者相比，脂肪因子阳性的患者 RFS 较差（p = 0.032）。在 Ki-67 高标记指数的 TNBC 患者中，脂肪因子阴性的患者 RFS 优于脂肪因子阳性的患者（p = 0.032）。此外，在未接受辅助化疗的患者中，脂肪因子阴性的患者 RFS 优于脂肪因子阳性的患者（p = 0.080）。多因素分析显示，脂肪因子表达与较高的复发率相关（风险比，4.89；95%置信区间，1.04-23.0；p = 0.044）。综上所述，这些结果表明脂肪因子是 TNBC 患者预后不良的一个新标志物。
