Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3LY, UK.
Dis Model Mech. 2013 Nov;6(6):1353-63. doi: 10.1242/dmm.011338.
An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this article, we review the recent findings that support the importance of lipid synthesis and metabolism in tumorigenesis. Specifically, we explore the role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis. These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality.
长期以来，人们一直认识到癌细胞代谢重编程的一个重要方面是脂质合成率的增加。然而，脂质对细胞转化、肿瘤发生和肿瘤进展的贡献，以及它们在促进癌细胞转移到继发部位方面的潜在作用，尚未得到充分理解。在本文中，我们回顾了支持脂质合成和代谢在肿瘤发生中的重要性的最新发现。具体来说，我们探讨了异常脂质生物合成在癌细胞迁移和侵袭以及肿瘤血管生成诱导中的作用。这些过程对于肿瘤细胞的播散和转移的形成至关重要，而转移是癌症死亡的主要原因。
