Department of Organic and Biomolecular Chemistry, Chemical Engineering Institute, Ural Federal University, 19 Mira Str., Yekaterinburg, K-2 620002, Russian Federation.
Org Biomol Chem. 2020 Dec 21;18(47):9562-9582. doi: 10.1039/d0ob01638a. Epub 2020 Nov 17.
The development of new methodologies for the synthesis of fluorinated organic molecules is in high demand due to their wide applications in agriculture and pharmaceutical sciences. Various strategies have been employed for this purpose for a long time. Arynes are well known synthetic intermediates and have gained the attention of synthetic chemists for the synthesis of various functionalized organic molecules. Consequently, these synthetic intermediates have been successfully employed in the synthesis of fluorinated organic moieties. Various useful fluorinated aromatic and heterocyclic molecules have been synthesized employing aryne intermediates. In this review, we will discuss all these methodologies developed in the last decade via aryne intermediates.
由于氟有机分子在农业和药物科学中的广泛应用，开发新的合成方法学的需求很高。长期以来，人们一直采用各种策略来实现这一目标。芳炔是众所周知的合成中间体，因其可用于合成各种功能化有机分子而受到合成化学家的关注。因此，这些合成中间体已成功用于氟有机部分的合成。各种有用的氟化芳族和杂环分子已通过芳炔中间体合成。在这篇综述中，我们将讨论过去十年中通过芳炔中间体开发的所有这些方法学。
