用于药物测试和再生医学的 3D 神经、血管和神经血管模型的进展。
Advances in 3D neural, vascular and neurovascular models for drug testing and regenerative medicine.
机构信息
3Bs Research Group, I3B's - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's - Portuguese Government Associate Laboratory, 4805-017 Braga/Guimarães, Portugal.
3Bs Research Group, I3B's - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Zona Industrial da Gandra, 4805-017 Barco GMR, Portugal; ICVS/3B's - Portuguese Government Associate Laboratory, 4805-017 Braga/Guimarães, Portugal.
出版信息
Drug Discov Today. 2021 Mar;26(3):754-768. doi: 10.1016/j.drudis.2020.11.009. Epub 2020 Nov 14.
Clinical trials continue to fall short regarding drugs to effectively treat brain-affecting diseases. Although there are many causes of these shortcomings, the most relevant are the inability of most therapeutic agents to cross the blood-brain barrier (BBB) and the failure to translate effects from animal models to patients. In this review, we analyze the most recent developments in BBB, neural, and neurovascular models, analyzing their impact on the drug development process by considering their quantitative and phenotypical characterization. We offer a perspective of the state-of-the-art of the models that could revolutionize the pharmaceutical industry.
临床试验在有效治疗影响大脑的疾病的药物方面仍存在不足。尽管这些不足有很多原因，但最相关的原因是大多数治疗剂无法穿过血脑屏障（BBB），以及无法将动物模型的效果转化为患者。在这篇综述中，我们分析了 BBB、神经和神经血管模型的最新进展，通过考虑它们的定量和表型特征来分析它们对药物开发过程的影响。我们提供了一个可能彻底改变制药行业的模型的最新技术视角。
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