鼻咽癌中的病毒标志物：p16、人乳头瘤病毒 (HPV) 和 EB 病毒 (EBV) 检测的系统评价和荟萃分析。
Viral markers in nasopharyngeal carcinoma: A systematic review and meta-analysis on the detection of p16, human papillomavirus (HPV), and Ebstein-Barr virus (EBV).
机构信息
Department of Otolaryngology, Zucker School of Medicine at Hofstra/Northwell, New York, USA.
Department of Otolaryngology, Zucker School of Medicine at Hofstra/Northwell, New York, USA.
出版信息
Am J Otolaryngol. 2021 Jan-Feb;42(1):102762. doi: 10.1016/j.amjoto.2020.102762. Epub 2020 Oct 20.
PURPOSE
This study aimed to conduct a meta-analysis to investigate the distribution of EBV and HPV stratified according to histological NPC type.
MATERIALS & METHODS: We performed a meta-analysis to produce pooled prevalence estimates in a random-effects model. We also performed calculations for attributable fractions of viral combinations in NPC, stratified according to histological type.
RESULTS
There was a higher prevalence of HPV DNA in WHO Type I (34.4%) versus WHO Type II/III (18.4%). The attributable fractions of WHO Type I NPC was predominantly double negative EBV(-) HPV(-) NPC (56.4%), and EBV(-) HPV(+) NPC (21.5%), in contrast to the predominant infection in WHO Type II/III which was EBV(+) HPV(-) NPC (87.5%). Co-infection of both EBV and HPV was uncommon, and double-negative infection was more common in WHO Type I NPC.
CONCLUSION
A significant proportion of WHO Type I NPC was either double-negative EBV(-)HPV(-) or EBV(-)HPV(+).
目的
本研究旨在进行荟萃分析，以调查根据组织学 NPC 类型分层的 EBV 和 HPV 的分布。
材料与方法
我们进行了荟萃分析，以随机效应模型生成汇总的患病率估计值。我们还根据组织学类型，对 NPC 中病毒组合的归因分数进行了计算。
结果
HPV DNA 在世界卫生组织（WHO）I 型（34.4%）中的流行率高于 WHO II/III 型（18.4%）。WHO I 型 NPC 的归因分数主要为 EBV(-)HPV(-) NPC（56.4%）和 EBV(-)HPV(+) NPC（21.5%），而 WHO II/III 型的主要感染则是 EBV(+)HPV(-) NPC（87.5%）。EBV 和 HPV 的双重感染并不常见，而在 WHO I 型 NPC 中，双阴性感染更为常见。
结论
相当一部分 WHO I 型 NPC 要么是 EBV(-)HPV(-)，要么是 EBV(-)HPV(+)。
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