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具有增强抗氧化和催化性能的生物合成金纳米颗粒。

Biologically Synthesized Gold Nanoparticles with Enhanced Antioxidant and Catalytic Properties.

作者信息

David Melinda, Enache Teodor A, Barbu-Tudoran Lucian, Bala Camelia, Florescu Monica

机构信息

Laboratory for Quality Control and Process Monitoring, University of Bucharest, 4-12 Elisabeta Blvd., 030018 Bucharest, Romania.

Department of Fundamental, Prophylactic and Clinical Disciplines, Faculty of Medicine, Transilvania University of Brasov, Str. Universitatii no. 1, 500068 Brasov, Romania.

出版信息

Pharmaceuticals (Basel). 2024 Aug 23;17(9):1105. doi: 10.3390/ph17091105.

DOI:10.3390/ph17091105
PMID:39338271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11434865/
Abstract

Increasing levels of reactive oxygen species generate oxidative stress in the human body that can lead to various medical conditions. The use of nanomaterials exhibiting antioxidant properties may prevent these effects. The biological synthesis of metallic nanoparticles using plant extracts with antioxidant properties can offer benefits due to their active compounds. The used extracts contained reducing and stabilizing agents, which were shown to be transferred onto the gold nanoparticles, functionalizing them. Herin, we report a gold nanoparticle synthesis by eco-friendly biological methods (b-AuNPs) using extracts of sea buckthorn, lavender, walnuts, and grapes, obtained through ultrasound-assisted extraction and pressure-enhanced extraction. The obtained b-AuNPs were characterized by UV-Vis and FTIR spectroscopies and visualized using transmission electron microscopy. The catalytic and scavenging effect of the b-AuNPs towards HO (as reactive oxygen species) was evaluated electrochemically, highlighting the protective behavior of b-AuNPs towards lipid peroxidation. All experiments demonstrated the stability and reproducibility of prepared b-AuNPs with enhanced antioxidant and catalytic properties, opening a new perspective for their use in biomedical applications.

摘要

活性氧水平的升高会在人体中产生氧化应激，进而可能导致各种医学病症。使用具有抗氧化特性的纳米材料或许可以预防这些影响。利用具有抗氧化特性的植物提取物进行金属纳米颗粒的生物合成，因其活性化合物而可能带来益处。所使用的提取物含有还原和稳定剂，这些物质被证明会转移到金纳米颗粒上，使其功能化。在此，我们报告了通过环保生物方法（b - AuNPs）合成金纳米颗粒，该方法使用了沙棘、薰衣草、核桃和葡萄的提取物，这些提取物通过超声辅助提取和压力强化提取获得。所得到的b - AuNPs通过紫外 - 可见光谱和傅里叶变换红外光谱进行表征，并使用透射电子显微镜进行可视化观察。通过电化学方法评估了b - AuNPs对HO（作为活性氧）的催化和清除作用，突出了b - AuNPs对脂质过氧化的保护行为。所有实验都证明了所制备的b - AuNPs具有稳定性和可重复性，且具有增强的抗氧化和催化特性，为其在生物医学应用中的使用开辟了新的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/c6edf7252909/pharmaceuticals-17-01105-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/d287031e3c45/pharmaceuticals-17-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/927f8ce4d671/pharmaceuticals-17-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/1c0c789734c5/pharmaceuticals-17-01105-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/cfb95fa63ad1/pharmaceuticals-17-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/f635b5976751/pharmaceuticals-17-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/f64b9d909aa9/pharmaceuticals-17-01105-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/0479b9ba3e19/pharmaceuticals-17-01105-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/b13f07a60fa1/pharmaceuticals-17-01105-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/c6edf7252909/pharmaceuticals-17-01105-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/d287031e3c45/pharmaceuticals-17-01105-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/927f8ce4d671/pharmaceuticals-17-01105-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/1c0c789734c5/pharmaceuticals-17-01105-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/cfb95fa63ad1/pharmaceuticals-17-01105-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/f635b5976751/pharmaceuticals-17-01105-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/f64b9d909aa9/pharmaceuticals-17-01105-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/0479b9ba3e19/pharmaceuticals-17-01105-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/b13f07a60fa1/pharmaceuticals-17-01105-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47fb/11434865/c6edf7252909/pharmaceuticals-17-01105-g009.jpg

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本文引用的文献

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