• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

原花青素和不同强度运动训练对心肌缺血中与Myh7和Myh6相关的微小RNA谱的调控作用

Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training.

作者信息

Zarei Safar, Taghian Farzaneh, Sharifi Gholamreza, Abedi Hassanali

机构信息

Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

Research Center for Non-Communicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran.

出版信息

Avicenna J Phytomed. 2025 Jan-Feb;15(1):874-889. doi: 10.22038/AJP.2024.24739.

DOI:10.22038/AJP.2024.24739
PMID:40271502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12013968/
Abstract

OBJECTIVE

Myocardial ischemia (MI) and circulatory arrest are associated with unfavorable cardiovascular outcomes. This study aims to investigate the effects of proanthocyanidins (PC) and regular exercise with various intensity training protocols (low, moderate, and high) on cardiac protection in a rat model of MI induced by isoproterenol.

MATERIALS AND METHODS

Based on bioinformatics, a pool of microRNAs and mRNAs was assessed according to significant differential expression in MI condition. Further, the networks of hub genes and mRNA-microRNAs were constructed. After 14 weeks of low, moderate, and high-intensity interval training and oral administration of 300 mg/kg of PC, MI was established in the rats by injecting isoproterenol. The real-time qPCR assessed the relative expressions.

RESULTS

Based on the analysis, (fibronectin-1) and Myh7 (myosin heavy chain 7) are potentially druggable cut points to reduce cardiac tissue damage. High-intensity interval training (HIIT) and consumption of PC modified the relative expression of Myh6 (myosin heavy chain 6), , and . Moreover, High-intensity interval training and PC regulated the mir92a-3p, mir181a-5p, mir29a-3p, and mir133a-3p.

CONCLUSION

Here, the data indicated that the HIIT protocol could have an effective strategy compared to low-intensity interval training (LIIT) and moderate-intensity interval training protocols (MIIT). Furthermore, HIIT and PC might have protective effects on the MI condition.

摘要

目的

心肌缺血（MI）和循环骤停与不良心血管结局相关。本研究旨在探讨原花青素（PC）以及不同强度训练方案（低、中、高）的规律运动对异丙肾上腺素诱导的大鼠MI模型心脏保护作用的影响。

材料与方法

基于生物信息学，根据MI状态下的显著差异表达评估一组微小RNA和信使核糖核酸。此外，构建了枢纽基因和信使核糖核酸-微小RNA网络。在进行14周的低、中、高强度间歇训练并口服300mg/kg的PC后，通过注射异丙肾上腺素在大鼠中建立MI模型。实时定量聚合酶链反应评估相对表达。

结果

基于分析，纤连蛋白-1和肌球蛋白重链7是减少心脏组织损伤的潜在可药物作用切点。高强度间歇训练（HIIT）和PC的摄入改变了肌球蛋白重链6、和的相对表达。此外，高强度间歇训练和PC调节了mir92a-3p、mir181a-5p、mir29a-3p和mir133a-3p。

结论

在此，数据表明与低强度间歇训练（LIIT）和中等强度间歇训练方案（MIIT）相比，HIIT方案可能是一种有效的策略。此外，HIIT和PC可能对MI状态具有保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/d5e969591a4f/AJP-15-874-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/0006204ad193/AJP-15-874-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/e0656ee992d2/AJP-15-874-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/f73825ebf49d/AJP-15-874-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/eb1f05863953/AJP-15-874-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/d5e969591a4f/AJP-15-874-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/0006204ad193/AJP-15-874-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/e0656ee992d2/AJP-15-874-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/f73825ebf49d/AJP-15-874-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/eb1f05863953/AJP-15-874-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64ad/12013968/d5e969591a4f/AJP-15-874-g005.jpg

相似文献

1
Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training.原花青素和不同强度运动训练对心肌缺血中与Myh7和Myh6相关的微小RNA谱的调控作用
Avicenna J Phytomed. 2025 Jan-Feb;15(1):874-889. doi: 10.22038/AJP.2024.24739.
2
Alternation of heart microRNA-mRNA network by high-intensity interval training and proanthocyanidin in myocardial ischemia rats: Artificial intelligence and validation experimental.高强度间歇训练和原花青素对心肌缺血大鼠心脏微小RNA-信使核糖核酸网络的改变：人工智能与验证实验
J Food Biochem. 2022 Dec;46(12):e14488. doi: 10.1111/jfbc.14488. Epub 2022 Oct 21.
3
The Exercise Preconditioning Effect on Cardiac Tissue Injury following Induction of Myocardial Infarction in Male Rats.运动预处理对雄性大鼠心肌梗死后心肌组织损伤的影响。
Biomed Res Int. 2023 Jul 13;2023:3631458. doi: 10.1155/2023/3631458. eCollection 2023.
4
Comparisons of High Intensity Interval Training and Continuous Training on Metabolomic Alteration and Cardiac Function in Male Adolescent Rats.高强度间歇训练与持续训练对雄性青春期大鼠代谢组学改变及心脏功能影响的比较
Front Physiol. 2022 Jun 28;13:900661. doi: 10.3389/fphys.2022.900661. eCollection 2022.
5
Effect of maximal-intensity and high-intensity interval training on exercise capacity and quality of life in patients with acute myocardial infarction: a randomized controlled trial.最大强度和高强度间歇训练对急性心肌梗死患者运动能力和生活质量的影响：一项随机对照试验。
Eur J Phys Rehabil Med. 2024 Feb;60(1):104-112. doi: 10.23736/S1973-9087.23.08094-2. Epub 2023 Oct 31.
6
Aerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats: Implications on oxidative balance, autophagy, and apoptosis.有氧间歇训练预处理方案可抑制异丙肾上腺素诱导的大鼠病理性心脏重塑：对氧化平衡、自噬和细胞凋亡的影响。
Sports Med Health Sci. 2024 Feb 2;6(4):344-357. doi: 10.1016/j.smhs.2024.01.010. eCollection 2024 Dec.
7
A comprehensive analysis of the impact of high-intensity interval vs. moderate-intensity continuous training on global and regional myocardial function in patients early after acute myocardial infarction - the STRAICT randomized controlled trial.高强度间歇训练与中等强度持续训练对急性心肌梗死后早期患者整体和局部心肌功能影响的综合分析——STRAICT随机对照试验
Eur J Prev Cardiol. 2025 Mar 5. doi: 10.1093/eurjpc/zwaf127.
8
Effects of Different Exercise Interventions on Cardiac Function in Rats With Myocardial Infarction.不同运动干预对心肌梗死大鼠心功能的影响。
Heart Lung Circ. 2021 May;30(5):773-780. doi: 10.1016/j.hlc.2020.08.004. Epub 2020 Sep 19.
9
Effects of high-intensity interval training on the expression of microRNA-499 and pro- and anti-apoptotic genes in doxorubicin-cardiotoxicity in rats.高强度间歇训练对大鼠阿霉素心脏毒性中微小RNA-499及促凋亡和抗凋亡基因表达的影响
J Electrocardiol. 2019 Jul-Aug;55:9-15. doi: 10.1016/j.jelectrocard.2019.02.009. Epub 2019 Feb 28.
10
The effect of preconditioning with high-intensity training on tissue levels of G-CSF, its receptor and C-kit after an acute myocardial infarction in male rats.高强度训练预处理对雄性大鼠急性心肌梗死后组织中 G-CSF、其受体和 C-kit 水平的影响。
BMC Cardiovasc Disord. 2020 Feb 11;20(1):75. doi: 10.1186/s12872-020-01380-w.

本文引用的文献

1
Antimicrobial Potential, Antioxidant Activity, and Phenolic Content of Grape Seed Extracts from Four Grape Varieties.四个葡萄品种葡萄籽提取物的抗菌潜力、抗氧化活性及酚类含量
Microorganisms. 2023 Feb 3;11(2):395. doi: 10.3390/microorganisms11020395.
2
A Cocktail of Polyherbal Bioactive Compounds and Regular Mobility Training as Senolytic Approaches in Age-dependent Alzheimer's: the In Silico Analysis, Lifestyle Intervention in Old Age.多种植物源生物活性化合物鸡尾酒疗法与规律运动训练作为年龄相关性阿尔茨海默病的衰老细胞清除方法：计算机模拟分析，老年生活方式干预
J Mol Neurosci. 2023 Mar;73(2-3):171-184. doi: 10.1007/s12031-022-02086-8. Epub 2023 Jan 12.
3
Natural remedies medicine derived from flaxseed (secoisolariciresinol diglucoside, lignans, and α-linolenic acid) improve network targeting efficiency of diabetic heart conditions based on computational chemistry techniques and pharmacophore modeling.
源自亚麻籽的天然药物（开环异落叶松脂素二葡萄糖苷、木脂素和α-亚麻酸）基于计算化学技术和药效团模型提高了糖尿病心脏疾病的网络靶向效率。
J Food Biochem. 2022 Dec;46(12):e14480. doi: 10.1111/jfbc.14480. Epub 2022 Oct 14.
4
Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities.葡萄籽原花青素提取物可抑制 DNA 和蛋白质损伤以及不稳定铁、酶和癌细胞活性。
Sci Rep. 2022 Jul 20;12(1):12393. doi: 10.1038/s41598-022-16608-2.
5
Cross Brain-Gut Analysis Highlighted Hub Genes and LncRNA Networks Differentially Modified During Leucine Consumption and Endurance Exercise in Mice with Depression-Like Behaviors.跨脑-肠分析强调了在有抑郁样行为的小鼠中，亮氨酸消耗和耐力运动期间差异修饰的枢纽基因和长链非编码 RNA 网络。
Mol Neurobiol. 2022 Jul;59(7):4106-4123. doi: 10.1007/s12035-022-02835-1. Epub 2022 Apr 27.
6
Antiapoptotic and anti-inflammatory effects of Pparγ agonist, pioglitazone, reversed Dox-induced cardiotoxicity through mediating of miR-130a downregulation in C57BL/6 mice.过氧化物酶体增殖物激活受体γ（Pparγ）激动剂吡格列酮的抗凋亡和抗炎作用通过介导C57BL/6小鼠中miR-130a的下调逆转了阿霉素诱导的心脏毒性。
J Biochem Mol Toxicol. 2022 Jun;36(6):e23041. doi: 10.1002/jbt.23041. Epub 2022 Mar 28.
7
The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review.微小RNA结合位点单核苷酸多态性作为胃癌和结直肠癌生物标志物的重要性：一项系统综述
J Pers Med. 2022 Mar 14;12(3):456. doi: 10.3390/jpm12030456.
8
The combination of endurance exercise and SGTC (Salvia-Ginseng-Trigonella-Cinnamon) ameliorate mitochondrial markers' overexpression with sufficient ATP production in the skeletal muscle of mice fed AGEs-rich high-fat diet.耐力运动与SGTC（丹参-人参-胡芦巴-肉桂）相结合，可改善富含晚期糖基化终末产物的高脂饮食喂养小鼠骨骼肌中线粒体标志物的过度表达，并产生足够的三磷酸腺苷。
Nutr Metab (Lond). 2022 Mar 5;19(1):17. doi: 10.1186/s12986-022-00652-w.
9
Physical activity ameliorates the function of organs via adipose tissue in metabolic diseases.体育锻炼通过脂肪组织改善代谢疾病中器官的功能。
Acta Histochem. 2022 Feb;124(2):151844. doi: 10.1016/j.acthis.2022.151844. Epub 2022 Jan 16.
10
Identification of MYH6 as the potential gene for human ischaemic cardiomyopathy.鉴定 MYH6 为人类缺血性心肌病的潜在基因。
J Cell Mol Med. 2021 Nov;25(22):10736-10746. doi: 10.1111/jcmm.17015. Epub 2021 Oct 26.