Nannarone Sara, De Monte Valentina, Arcelli Rolando, Menchetti Laura, Gialletti Rodolfo
Department of Veterinary Medicine, Perugia University, 06126 Perugia, Italy.
Department of Agricultural and Food Sciences, University of Bologna, Viale Fanin 44, 40127 Bologna, Italy.
Animals (Basel). 2020 Nov 13;10(11):2110. doi: 10.3390/ani10112110.
Nineteen raccoons were enrolled in this study. The aim was to evaluate and compare the quality of anesthesia and the cardiorespiratory effects following treatment with a ketamine-based combination with either dexmedetomidine (KD group) or midazolam (KM group) in raccoons undergoing ovariohysterectomy/orchiectomy. General anesthesia was maintained with sevoflurane in oxygen and sufentanil infusion. The time required to approach the animals was similar among groups resulting in a median of 5 min after IM injection. Animals in group KD were scored with greater myorelaxation ( < 0.01) and easier intubation ( < 0.05). Moreover 70% of them did not require other drugs for tracheal intubation unlike animals in group KM, which required propofol in 100% of cases. After intubation and connection to the breathing circuit, physiological parameters were monitored continuously and recorded every 5 min. Sevoflurane requirements were lower in group KD than KM ( = 0.005). Blood pressure was maintained within physiological ranges in both groups but with higher values in group KM ( < 0.05). Mild respiratory depression occurred during surgery and animals in group KM showed greater respiratory acidosis ( < 0.05). Recovery was smooth and uneventful in all animals. Both anesthetic protocols can be recommended for safe anesthesia in wild raccoons.
本研究纳入了19只浣熊。目的是评估和比较在接受卵巢子宫切除术/睾丸切除术的浣熊中，使用基于氯胺酮的联合用药（分别与右美托咪定联合，KD组；或与咪达唑仑联合，KM组）后的麻醉质量和心肺效应。全身麻醉通过氧气中的七氟醚和舒芬太尼输注维持。接近动物所需的时间在各组之间相似，肌肉注射后中位数为5分钟。KD组动物的肌肉松弛评分更高（<0.01），插管更容易（<0.05）。此外，与KM组动物不同，KD组70%的动物气管插管不需要其他药物，而KM组100%的动物需要丙泊酚。插管并连接呼吸回路后，持续监测生理参数，每5分钟记录一次。KD组的七氟醚需求量低于KM组（P = 0.005）。两组的血压均维持在生理范围内，但KM组的值更高（<0.05）。手术期间出现轻度呼吸抑制，KM组动物表现出更严重的呼吸性酸中毒（<0.05）。所有动物恢复顺利且无并发症。两种麻醉方案均可推荐用于野生浣熊的安全麻醉。
