CLDN10 与免疫浸润相关，是透明细胞肾细胞癌的一种新的预后生物标志物。
CLDN10 associated with immune infiltration is a novel prognostic biomarker for clear cell renal cell carcinoma.
机构信息
Department of Urology, Peking University First Hospital, Beijing 100034, P.R. China.
Hereditary Kidney Cancer Research Center, Peking University First Hospital, Beijing 100034, P.R. China.
出版信息
Epigenomics. 2021 Jan;13(1):31-45. doi: 10.2217/epi-2020-0256. Epub 2020 Nov 18.
To identify the clinical roles of CLDN10 in clear cell renal cell carcinoma (ccRCC). Using data from TCGA-KIRC, GEO DataSets and laboratory experiments to determine the prognostic and clinicopathological characteristics of CLDN10. CLDN10 expression was remarkably reduced in ccRCC. Downregulated CLDN10 was related to metastasis and poor prognosis. Multivariate Cox analysis determined that elevated CLDN10 expression was independently correlated with longer OS and DFS. Moreover, CLDN10 expression was negatively associated with the methylation levels of cg10305311 and cg16275739. CLDN10 expression was also associated with naive CD4 and memory T-cell and dendritic cell infiltration. Immune-related CLDN10 is an independent prognostic biomarker of ccRCC. DNA hypermethylation plays an important role in decreased CLDN10 expression.
为了明确 CLDN10 在肾透明细胞癌（ccRCC）中的临床作用。我们使用来自 TCGA-KIRC、GEO DataSets 和实验室实验的数据，来确定 CLDN10 的预后和临床病理特征。CLDN10 在 ccRCC 中表达显著降低。下调的 CLDN10 与转移和不良预后有关。多变量 Cox 分析确定，CLDN10 表达升高与更长的 OS 和 DFS 独立相关。此外，CLDN10 表达与 cg10305311 和 cg16275739 的甲基化水平呈负相关。CLDN10 表达还与幼稚 CD4 和记忆 T 细胞和树突状细胞浸润有关。免疫相关的 CLDN10 是 ccRCC 的一个独立预后生物标志物。DNA 超甲基化在 CLDN10 表达降低中起重要作用。
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