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基于铜死亡相关基因的肾透明细胞癌分子分型及肿瘤微环境浸润特征分析

Molecular Subtyping Based on Cuproptosis-Related Genes and Characterization of Tumor Microenvironment Infiltration in Kidney Renal Clear Cell Carcinoma.

作者信息

Ji Zhong-Hao, Ren Wen-Zhi, Wang Hao-Qi, Gao Wei, Yuan Bao

机构信息

Department of Laboratory Animals, College of Animal Sciences, Jilin University, Changchun, China.

Department of Basic Medicine, Changzhi Medical College, Changzhi, China.

出版信息

Front Oncol. 2022 Jul 6;12:919083. doi: 10.3389/fonc.2022.919083. eCollection 2022.

DOI:10.3389/fonc.2022.919083
PMID:35875087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9299088/
Abstract

The incidence of kidney renal clear cell carcinoma (KIRC) is rising worldwide, and the prognosis is poor. Cuproptosis is a new form of cell death that is dependent on and regulated by copper ions. The relationship between cuproptosis and KIRC remains unclear. In the current study, changes in cuproptosis-related genes (CRGs) in TCGA-KIRC transcriptional datasets were characterized, and the expression patterns of these genes were analyzed. We identified three main molecular subtypes and discovered that multilayer CRG changes were associated with patient clinicopathological traits, prognosis, elesclomol sensitivity, and tumor microenvironment (TME) cell infiltration characteristics. Then, a CRG score was created to predict overall survival (OS). The CRG score was found to be strongly linked to the TME. These findings may help elucidate the roles of CRGs in KIRC, potentially enhancing understanding of cuproptosis and supporting the development of more effective immunotherapy strategies.

摘要

肾透明细胞癌（KIRC）的发病率在全球范围内呈上升趋势，且预后较差。铜死亡是一种依赖于铜离子并受其调节的新型细胞死亡形式。铜死亡与KIRC之间的关系仍不清楚。在本研究中，我们对TCGA-KIRC转录数据集中铜死亡相关基因（CRGs）的变化进行了表征，并分析了这些基因的表达模式。我们确定了三种主要分子亚型，并发现多层CRG变化与患者临床病理特征、预后、埃斯克洛莫尔敏感性和肿瘤微环境（TME）细胞浸润特征相关。然后，创建了一个CRG评分来预测总生存期（OS）。发现CRG评分与TME密切相关。这些发现可能有助于阐明CRGs在KIRC中的作用， potentially enhancing understanding of cuproptosis and supporting the development of more effective immunotherapy strategies. （原文最后一句中“potentially enhancing...”部分翻译后感觉不太通顺，推测可能是表述有误，按照字面翻译了。）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/ba7d56645ea8/fonc-12-919083-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/7d0e9670c825/fonc-12-919083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/b935814e6998/fonc-12-919083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/6132d5385d4c/fonc-12-919083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/a8bbbc26313a/fonc-12-919083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/9496b9cda57e/fonc-12-919083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/0c793ad0eaca/fonc-12-919083-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/b35a5b95d11d/fonc-12-919083-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/ba7d56645ea8/fonc-12-919083-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/7d0e9670c825/fonc-12-919083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/b935814e6998/fonc-12-919083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/6132d5385d4c/fonc-12-919083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/a8bbbc26313a/fonc-12-919083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/9496b9cda57e/fonc-12-919083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/0c793ad0eaca/fonc-12-919083-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/b35a5b95d11d/fonc-12-919083-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a7/9299088/ba7d56645ea8/fonc-12-919083-g008.jpg

相似文献

[1]
Molecular Subtyping Based on Cuproptosis-Related Genes and Characterization of Tumor Microenvironment Infiltration in Kidney Renal Clear Cell Carcinoma.

Front Oncol. 2022-7-6

[2]
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[3]
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[4]
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[5]
The signature genes of cuproptosis associates with tumor immune microenvironment and predicts prognosis in kidney renal clear cell carcinoma.

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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
The role of cuproptosis-related genes in pan-cancer and the development of cuproptosis-related risk model in colon adenocarcinoma.

Heliyon. 2024-7-2

[2]
Unravelling infiltrating T-cell heterogeneity in kidney renal clear cell carcinoma: Integrative single-cell and spatial transcriptomic profiling.

J Cell Mol Med. 2024-6

[3]
Mechanisms of cuproptosis and its relevance to distinct diseases.

Apoptosis. 2024-8

[4]
Crosstalk between metabolism and cell death in tumorigenesis.

Mol Cancer. 2024-4-4

[5]
Identification and validation of a copper homeostasis-related gene signature for the predicting prognosis of breast cancer patients via integrated bioinformatics analysis.

Sci Rep. 2024-2-7

[6]
Novel cuproptosis-related prognostic gene profiles in preeclampsia.

BMC Pregnancy Childbirth. 2024-1-10

[7]
Crosstalk of cuproptosis-related prognostic signature and competing endogenous RNAs regulation in hepatocellular carcinoma.

Aging (Albany NY). 2023-12-10

[8]
Machine learning algorithms for a novel cuproptosis-related gene signature of diagnostic and immune infiltration in endometriosis.

Sci Rep. 2023-12-7

[9]
A novel cuproptosis pattern and tumor immune microenvironment characterization in urothelial carcinoma of the bladder.

Front Immunol. 2023

[10]
Cuproptosis-related gene expression is associated with immune infiltration and CD47/CD24 expression in glioblastoma, and a risk score based on these genes can predict the survival and prognosis of patients.

Front Oncol. 2023-7-20

本文引用的文献

[1]
Copper induces cell death by targeting lipoylated TCA cycle proteins.

Science. 2022-3-18

[2]
Generation and Analysis of Pyroptosis-Based and Immune-Based Signatures for Kidney Renal Clear Cell Carcinoma Patients, and Cell Experiment.

Front Genet. 2022-2-24

[3]
The Downregulation of Prognosis- and Immune Infiltration-Related Gene CYFIP2 Serves as a Novel Target in ccRCC.

Int J Gen Med. 2021-10-11

[4]
FDX1 can Impact the Prognosis and Mediate the Metabolism of Lung Adenocarcinoma.

Front Pharmacol. 2021-10-8

[5]
CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair.

Cell Death Dis. 2021-8-14

[6]
Elesclomol induces copper-dependent ferroptosis in colorectal cancer cells via degradation of ATP7A.

Mol Oncol. 2021-12

[7]
A novel ferroptosis-related 12-gene signature predicts clinical prognosis and reveals immune relevancy in clear cell renal cell carcinoma.

BMC Cancer. 2021-7-19

[8]
Elesclomol-induced increase of mitochondrial reactive oxygen species impairs glioblastoma stem-like cell survival and tumor growth.

J Exp Clin Cancer Res. 2021-7-12

[9]
The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS).

BMC Endocr Disord. 2021-6-15

[10]
A novel ENAM mutation causes hypoplastic amelogenesis imperfecta.

Oral Dis. 2022-9

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