Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
Department of Chemistry, Higher Teacher Training College, University of Yaounde I, Yaounde, Cameroon.
Nat Prod Res. 2022 Apr;36(8):2085-2096. doi: 10.1080/14786419.2020.1849199. Epub 2020 Nov 18.
Two new fatty acid esters of triterpenoids (-) together with eleven known compounds (-) were obtained after investigation of the CHCl-MeOH (1:1) crude extract from the leaves of Harms. All these compounds (-) were isolated for the first time from this plant among which compounds , , and - were also isolated from the genus for the first time. The structures of the isolated compounds were elucidated by analyses of their spectroscopic data (1D and 2D NMR, and MS). The antibacterial and cytotoxic activities of crude extracts, fractions and compounds (, , , , and ) were investigated against both Gram-negative and Gram-positive bacteria strains as well as on human cervix carcinoma and colon adenocarcinoma cancer cell lines, respectively. They showed weak to significant activity towards the strains and malignant cells used.
从 Harms 叶的 CHCl-MeOH（1:1）粗提物中分离得到两种新的三萜脂肪酸酯（-）和 11 种已知化合物（-）。这些化合物（-）均为首次从该植物中分离得到，其中化合物 、 、 和 - 也是首次从属中分离得到。通过分析其光谱数据（1D 和 2D NMR、MS）阐明了分离化合物的结构。对粗提取物、馏分和化合物（、、、、和 ）进行了抗菌和细胞毒性活性测试，分别针对革兰氏阴性和革兰氏阳性菌菌株以及人宫颈癌细胞和结肠腺癌细胞系。它们对所用的菌株和恶性细胞表现出弱至显著的活性。
