Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, Reus, Spain; Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Reus, Spain.
Universitat Rovira i Virgili, Facultat de Medicina i Ciències de la Salut, Functional Nutrition, Oxidation, and Cardiovascular Diseases Group (NFOC-Salut), Reus, Spain.
Food Chem. 2021 May 15;344:128567. doi: 10.1016/j.foodchem.2020.128567. Epub 2020 Nov 7.
In the present study, potential associations between dietary phenolic compounds (PCs), gut microbiota composition and targeted faecal metabolites were identified in a cross-sectional study including grade 1 hypertensive (HT) and normotensive (NT) subjects. We performed comprehensive quantification of PC intake, together with 16S rRNA gene sequencing of the gut microbiota, and faecal and plasma short-chain fatty acids (SCFAs) determination. The results showed multiple-way relationships between PCs from several plant-based foods and 25 bacterial taxa previously defined as discriminant biomarkers among groups. Remarkably, coffee PCs were positively associated with systolic and diastolic blood pressure, faecal SCFAs, Bacteroides plebeius and Bacteroides coprocola in HT and negatively associated with Faecalibacterium prausnitzii and Christensenellaceae R-7 in NT. Olive fruit PCs were positively associated with Ruminococcaceae UCG-010, Christensenellaceae R-7 and plasma SCFAs in NT. These interplays with discriminant bacterial taxa in HT and NT subjects highlight the potential role of specific PCs as gut microbiome modulators in either the pathogenesis or prevention of hypertension.
在这项横断面研究中，研究人员在包括 1 级高血压 (HT) 和血压正常 (NT) 受试者的人群中，鉴定了膳食酚类化合物 (PCs)、肠道微生物群落组成和靶向粪便代谢物之间的潜在关联。研究人员进行了 PCs 摄入量的综合定量分析，同时对肠道微生物群落进行了 16S rRNA 基因测序，并测定了粪便和血浆短链脂肪酸 (SCFAs)。结果表明，来自几种植物性食物的 PCs 与 25 种先前被定义为组间区分标志物的细菌分类群之间存在多向关系。值得注意的是，咖啡 PCs 与 HT 患者的收缩压和舒张压、粪便 SCFAs、拟杆菌属和丁酸梭菌呈正相关，与 NT 患者的普拉梭菌和克里斯滕森菌科 R-7 呈负相关。橄榄果 PCs 与 NT 患者的瘤胃球菌科 UCG-010、克里斯滕森菌科 R-7 和血浆 SCFAs 呈正相关。这些在 HT 和 NT 受试者中与区分细菌分类群的相互作用突出了特定 PCs 作为肠道微生物组调节剂在高血压发病机制或预防中的潜在作用。
