谷胱甘肽 S-转移酶基因多态性对 2 型糖尿病发病年龄的影响。
Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset.
机构信息
Collegium Medicum, Jan Kochanowski University of Kielce, Kielce, Poland
Collegium Medicum, Jan Kochanowski University of Kielce, Kielce, Poland.
出版信息
BMJ Open Diabetes Res Care. 2020 Nov;8(2). doi: 10.1136/bmjdrc-2020-001773.
INTRODUCTION
Type 2 diabetes (T2D) is a multifactorial disease affecting mostly adults older than 40 years. The aim of the study was to examine gene polymorphism influence on the risk of T2D, especially in young adults.
RESEARCH DESIGN AND METHODS
200 diabetic patients and 221 healthy controls participated in this study. Three gene polymorphism have been analyzed: (single-nucleotide polymorphism IleVal), homozygous deletion of (null/null) and (null/null), using TaqMan real-time quantitative PCR.
RESULTS
The distribution of examined polymorphisms was similar in patient group and control group. Statistically significant differences were demonstrated for the combination of and / genotypes between patients diagnosed before 40 years of age and healthy people (12.5% vs 0.9%, p=0.016). Moreover, all three examined gene polymorphism together (, and genotype) was observed in 12.5% of patients diagnosed before 40 years of age and in 0.5% of healthy individuals (p=0.013).
CONCLUSION
In conclusion, the results suggest that polymorphism may be one of the risk factors for developing T2D at a younger age than the T2D population average.
简介
2 型糖尿病（T2D）是一种影响大多数 40 岁以上成年人的多因素疾病。本研究旨在探讨基因多态性对 T2D 风险的影响，特别是在年轻成年人中。
研究设计和方法
本研究纳入了 200 例糖尿病患者和 221 名健康对照者。使用 TaqMan 实时定量 PCR 分析了三个基因多态性：（IleVal 单核苷酸多态性）、（纯合缺失型）和（纯合缺失型）。
结果
在患者组和对照组中，所检查的多态性的分布相似。在 40 岁以下被诊断为患者的人群和健康人群之间，（、/基因型的组合存在统计学显著差异（12.5% vs 0.9%，p=0.016）。此外，在所有三种被检查的基因多态性（、和基因型）中，在 40 岁以下被诊断为患者的人群中观察到 12.5%，而在健康人群中观察到 0.5%（p=0.013）。
结论
总之，结果表明，基因多态性可能是比 T2D 人群平均年龄更早发生 T2D 的风险因素之一。
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