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表现为急性下腔静脉综合征的耗竭性睾丸生殖细胞肿瘤。

Burned-out testicular germ cell tumour presenting as acute inferior vena cava syndrome.

机构信息

Radiology, London North West University Healthcare NHS Trust, Harrow, London, UK.

Urology, London North West University Healthcare NHS Trust, Harrow, London, UK

出版信息

BMJ Case Rep. 2020 Nov 17;13(11):e237481. doi: 10.1136/bcr-2020-237481.

Abstract

Germ cell tumours (GCT) are the most common testicular neoplasms, seen mainly in young adults. Rarely they can affect extragonadal tissues, either as primary tumours or as metastases, most commonly to retroperitoneal lymph nodes. A 'burned-out' testicular tumour is a metastatic GCT with a relatively occult primary testicular tumour, which has histologically spontaneously regressed. We report a case of a 26-year-old man who presented with an acute history of lower back pain and leg swelling. CT demonstrated a large retroperitoneal soft tissue mass causing right-sided hydronephrosis with inferior vena cava and iliofemoral vein thrombosis. Although clinical examination of the testis was normal, ultrasound imaging of the scrotum identified a burned-out testicular primary. Orchiectomy confirmed the diagnosis and the patient responded well to chemotherapy, with no viable residual tumour on follow-up imaging. However, despite nephrostomy insertion, a dimercaptosuccinic acid (DMSA) scan demonstrated loss of function of the right kidney after treatment.

摘要

生殖细胞肿瘤(GCT)是最常见的睾丸肿瘤,主要见于年轻人。它们很少会影响性腺外组织,无论是作为原发性肿瘤还是作为转移瘤,最常见的是腹膜后淋巴结。“耗竭性”睾丸肿瘤是一种转移性 GCT,具有相对隐匿的原发性睾丸肿瘤,其组织学上自发消退。我们报告了一例 26 岁男性,以下腰痛和腿部肿胀的急性病史就诊。CT 显示腹膜后巨大软组织肿块导致右侧肾盂积水和下腔静脉及髂股静脉血栓形成。虽然睾丸检查正常,但阴囊超声检查发现原发性睾丸肿瘤已耗竭。睾丸切除术证实了诊断,患者对化疗反应良好,随访影像学检查未见存活的残留肿瘤。然而,尽管插入了肾造口管,二巯丁二酸(DMSA)扫描显示治疗后右肾功能丧失。

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