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植物乳杆菌 TA4 细胞生物质及其上清液合成氧化锌纳米粒子及其抗菌和生物相容性。

Biosynthesis of zinc oxide nanoparticles by cell-biomass and supernatant of Lactobacillus plantarum TA4 and its antibacterial and biocompatibility properties.

机构信息

Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

Bioprocessing and Biomanufacturing Research Centre, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.

出版信息

Sci Rep. 2020 Nov 17;10(1):19996. doi: 10.1038/s41598-020-76402-w.

DOI:10.1038/s41598-020-76402-w
PMID:33204003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7673015/
Abstract

This study aims to utilize the cell-biomass (CB) and supernatant (CFS) of zinc-tolerant Lactobacillus plantarum TA4 as a prospective nanofactory to synthesize ZnO NPs. The surface plasmon resonance for the biosynthesized ZnO NPs-CFS and ZnO NPs-CB was 349 nm and 351 nm, respectively, thereby confirming the formation of ZnO NPs. The FTIR analysis revealed the presence of proteins, carboxyl, and hydroxyl groups on the surfaces of both the biosynthesized ZnO NPs that act as reducing and stabilizing agents. The DLS analysis revealed that the poly-dispersity indexes was less than 0.4 for both ZnO NPs. In addition, the HR-TEM micrographs of the biosynthesized ZnO NPs revealed a flower-like pattern for ZnO NPs-CFS and an irregular shape for ZnO NPs-CB with particles size of 291.1 and 191.8 nm, respectively. In this study, the biosynthesized ZnO NPs exhibited antibacterial activity against pathogenic bacteria in a concentration-dependent manner and showed biocompatibility with the Vero cell line at specific concentrations. Overall, CFS and CB of L. plantarum TA4 can potentially be used as a nanofactory for the biological synthesis of ZnO NPs.

摘要

本研究旨在利用耐锌植物乳杆菌 TA4 的细胞生物质 (CB) 和上清液 (CFS) 作为潜在的纳米工厂来合成 ZnO NPs。生物合成的 ZnO NPs-CFS 和 ZnO NPs-CB 的表面等离子体共振分别为 349nm 和 351nm，从而证实了 ZnO NPs 的形成。FTIR 分析表明，生物合成的 ZnO NPs 表面存在蛋白质、羧基和羟基，它们作为还原剂和稳定剂。DLS 分析表明，两种 ZnO NPs 的多分散指数均小于 0.4。此外，生物合成 ZnO NPs 的 HR-TEM 显微照片显示 ZnO NPs-CFS 呈花状，而 ZnO NPs-CB 呈不规则形状，粒径分别为 291.1nm 和 191.8nm。在这项研究中，生物合成的 ZnO NPs 表现出对致病菌的浓度依赖性抗菌活性，并在特定浓度下对 Vero 细胞系表现出生物相容性。总的来说，植物乳杆菌 TA4 的 CFS 和 CB 可以潜在地用作 ZnO NPs 生物合成的纳米工厂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/edd5c10194c5/41598_2020_76402_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/2a5893dabc14/41598_2020_76402_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/a141c2afccfc/41598_2020_76402_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/cb78c41479a3/41598_2020_76402_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/88990892865f/41598_2020_76402_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/e452f3e5be30/41598_2020_76402_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/7b193068c994/41598_2020_76402_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/ce289cf04acd/41598_2020_76402_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/c6a54ea2a275/41598_2020_76402_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/0cc5089b24a1/41598_2020_76402_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/edd5c10194c5/41598_2020_76402_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/2a5893dabc14/41598_2020_76402_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/a141c2afccfc/41598_2020_76402_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/cb78c41479a3/41598_2020_76402_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/88990892865f/41598_2020_76402_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/e452f3e5be30/41598_2020_76402_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/7b193068c994/41598_2020_76402_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/ce289cf04acd/41598_2020_76402_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/c6a54ea2a275/41598_2020_76402_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/0cc5089b24a1/41598_2020_76402_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36c3/7673015/edd5c10194c5/41598_2020_76402_Fig10_HTML.jpg

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本文引用的文献

[1]
A bio-inspired strategy for the synthesis of zinc oxide nanoparticles (ZnO NPs) using the cell extract of cyanobacterium sp. EA03: from biological function to toxicity evaluation.

RSC Adv. 2019-7-29

[2]
Sustainable microbial cell nanofactory for zinc oxide nanoparticles production by zinc-tolerant probiotic Lactobacillus plantarum strain TA4.

Microb Cell Fact. 2020-1-15

[3]
Synthesis of Silver Nanoparticles Mediated by Fungi: A Review.

Front Bioeng Biotechnol. 2019-10-22

[4]
ZnO Nanostructures and Electrospun ZnO-Polymeric Hybrid Nanomaterials in Biomedical, Health, and Sustainability Applications.

Nanomaterials (Basel). 2019-10-12

[5]
Green Bio-Assisted Synthesis, Characterization and Biological Evaluation of Biocompatible ZnO NPs Synthesized from Different Tissues of Milk Thistle ().

Nanomaterials (Basel). 2019-8-16

[6]
Fungal formation of selenium and tellurium nanoparticles.

Appl Microbiol Biotechnol. 2019-7-20

[7]
Microbial synthesis of zinc oxide nanoparticles and their potential application as an antimicrobial agent and a feed supplement in animal industry: a review.

J Anim Sci Biotechnol. 2019-7-9

[8]
Phytofabrication of Selenium Nanoparticles From Fruit Extract and Exploring Its Biopotential Applications: Antioxidant, Antimicrobial, and Biocompatibility.

Front Microbiol. 2019-4-30

[9]
A multiparametric study of gold nanoparticles cytotoxicity, internalization and permeability using an model of blood-brain barrier. Influence of size, shape and capping agent.

Nanotoxicology. 2019-6-8

[10]
Phycosynthesis and Enhanced Photocatalytic Activity of Zinc Oxide Nanoparticles Toward Organosulfur Pollutants.

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