El-Saadony Mohamed T, Fang Guihong, Yan Si, Alkafaas Samar Sami, El Nasharty Mahmoud A, Khedr Sohila A, Hussien Aya Misbah, Ghosh Soumya, Dladla Mthokozisi, Elkafas Sara Samy, Ibrahim Essam H, Salem Heba Mohammed, Mosa Walid F A, Ahmed Ahmed Ezzat, Mohammed Dina Mostafa, Korma Sameh A, El-Tarabily Marawan K, Saad Ahmed M, El-Tarabily Khaled A, AbuQamar Synan F
Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.
School of Public Health, Heinz Mehlhorn Academician Workstation, Hainan Medical University, Haikou, Hainan, 571199, People's Republic of China.
Int J Nanomedicine. 2024 Dec 3;19:12889-12937. doi: 10.2147/IJN.S487188. eCollection 2024.
Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for their wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, and drug/gene delivery. Among these, zinc oxide (ZnO) NPs stand out for their versatility and effectiveness. Recently, ZnO NPs have become a primary material in various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, and automotive industries. ZnO NPs can generate reactive oxygen species and induce cellular apoptosis, thus underpinning their potent anticancer and antibacterial properties. To meet the growing demand, numerous synthetic approaches have been developed to produce ZnO NPs. However, traditional manufacturing processes often involve significant economic and environmental costs, prompting a search for more sustainable alternatives. Intriguingly, biological synthesis methods utilizing plants, plant extracts, or microorganisms have emerged as ideal for producing ZnO NPs. These green production techniques offer numerous medicinal, economic, environmental, and health benefits. This review highlights the latest advancements in the green synthesis of ZnO NPs and their biomedical applications, showcasing their potential to revolutionize the field with eco-friendly and cost-effective solutions.
在过去十年中，生物医学纳米材料因其卓越的生物学特性以及在生物医学领域的广泛应用而备受关注。金属氧化物纳米颗粒（NPs）因其广泛的药用用途而尤为显著，包括抗菌、抗癌、生物传感、细胞成像以及药物/基因递送等。其中，氧化锌（ZnO） NPs因其多功能性和有效性而脱颖而出。最近，ZnO NPs已成为制药、化妆品、抗菌、建筑、纺织和汽车等各个行业的主要材料。ZnO NPs可产生活性氧并诱导细胞凋亡，从而支撑其强大的抗癌和抗菌特性。为满足不断增长的需求，人们已开发出多种合成方法来制备ZnO NPs。然而，传统制造工艺往往涉及高昂的经济和环境成本，这促使人们寻找更具可持续性的替代方法。有趣的是，利用植物、植物提取物或微生物的生物合成方法已成为制备ZnO NPs的理想选择。这些绿色生产技术具有诸多医学、经济、环境和健康益处。本综述重点介绍了ZnO NPs绿色合成及其生物医学应用的最新进展，展示了它们通过环保且经济高效的解决方案彻底改变该领域的潜力。
