Sugai S, Tachibana J, Sawada M, Shimizu S, Hirose Y, Takiguchi T, Konda S
Department of Internal Medicine, Kanazawa Medical University, Ishikawa Pref., Japan.
Jpn J Med. 1987 Aug;26(3):339-47. doi: 10.2169/internalmedicine1962.26.339.
Six patients with malignant lymphomas in autoimmune diseases are described. Four patients who had Sjögren's syndrome (SS) alone or with progressive systemic sclerosis (PSS) or rheumatoid arthritis (RA) developed non-Hodgkin's lymphomas of the B cell type. One patient who had systemic lupus erythematosus (SLE) developed a B cell lymphoma. Another patient with chronic thyroiditis (ChTD) and idiopathic thrombocytopenic purpura (ITP) had a T cell (OKT3/T4) lymphoma. In 5 patients, the autoimmune diseases (2SS, SS/PSS, SS/RA and SLE) preceded B cell lymphomas by one to 11 years. In the patient with ChTD/ITP, ChTD and a malignant lymphoma were found simultaneously. A review of Japanese reports on lymphoproliferative disorders associated with these autoimmune diseases is given. This report offers the suggestion that disorders in the immunoregulatory system caused by autoimmune diseases may predispose lymphoproliferative disorders.
本文描述了6例自身免疫性疾病合并恶性淋巴瘤的患者。4例单独患有干燥综合征（SS）或合并进行性系统性硬化症（PSS）或类风湿关节炎（RA）的患者发生了B细胞型非霍奇金淋巴瘤。1例患有系统性红斑狼疮（SLE）的患者发生了B细胞淋巴瘤。另1例患有慢性甲状腺炎（ChTD）和特发性血小板减少性紫癜（ITP）的患者患有T细胞（OKT3/T4）淋巴瘤。5例患者中，自身免疫性疾病（2例SS、SS/PSS、SS/RA和SLE）在B细胞淋巴瘤出现前1至11年。在患有ChTD/ITP的患者中，ChTD和恶性淋巴瘤同时被发现。本文对日本有关这些自身免疫性疾病相关淋巴增殖性疾病的报告进行了综述。本报告提示，自身免疫性疾病引起的免疫调节系统紊乱可能易患淋巴增殖性疾病。
