丙戊酸对正常受试者苯妥英清除率的影响。
Modification of phenytoin clearance by valproic acid in normal subjects.
作者信息
Frigo G M, Lecchini S, Gatti G, Perucca E, Crema A
出版信息
Br J Clin Pharmacol. 1979 Dec;8(6):553-6. doi: 10.1111/j.1365-2125.1979.tb01043.x.
Abstract
1 The effect of valproic acid on the distribution and elimination kinetics of intravenously administered phenytoin has been investigated in eight normal volunteers. 2 In each of the subjects studied the volume of distribution of phenytoin increased significantly during treatment with sodium valproate (1200 mg daily for 7 days). 3 Phenytoin clearance was markedly increased in presence of valproic acid as compared to control values (0.52 +/- 0.17 v 0.38 +/- 0.11 ml min-1 kg-1 respectively, P less than 0.02). 4 It is suggested that the increase of the volume of distribution and of the serum clearance are secondary to displacement of phenytoin from plasma protein binding sites by valproic acid.
摘要
- 已在8名正常志愿者中研究了丙戊酸对静脉注射苯妥英钠分布和消除动力学的影响。2. 在每个研究对象中，丙戊酸钠治疗期间（每日1200毫克，共7天）苯妥英钠的分布容积显著增加。3. 与对照值相比，丙戊酸存在时苯妥英钠清除率明显增加（分别为0.52±0.17对0.38±0.11毫升·分钟⁻¹·千克⁻¹，P＜0.02）。4. 提示分布容积和血清清除率的增加是由于丙戊酸将苯妥英钠从血浆蛋白结合位点置换出来所致。
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