Radiation Oncology Service, Provincial Hospital of Castellón, Avda. Dr. Clara 19, 12002, Castellón de la Plana, Spain.
Hyperbaric Therapy Unit, General Hospital of Castellón, Castellón de la Plana, Spain.
Clin Transl Oncol. 2021 Jun;23(6):1047-1053. doi: 10.1007/s12094-020-02513-5. Epub 2020 Nov 18.
About 5% of cancer patients treated with radiotherapy will have severe late-onset toxicity. Hyperbaric oxygen therapy (HBOT) has been used as a treatment for radiation injuries for decades, with many publications presenting data from small series or individual cases. Moreover, we know that the hypoxic areas of tumours are more resistant to radiation. HBOT increases the oxygen tension in tissues and, theoretically, it should enhance the efficiency of radiotherapy. To better understand how HBOT works, we carried out this bibliographic review. We found Grade B and C evidence that at pressures exceeding 2 absolute atmospheres (ata), HBOT reduced late-onset radiation injuries to the head and neck, bone, prostate and bladder. It also appeared to prevent osteoradionecrosis after exodontia in irradiated areas. Finally, HBOT at 2 ata increased the effectiveness of radiation in head and neck tumours and achieved promising results in the local control of high-grade gliomas.
约 5%接受放疗的癌症患者会出现严重的迟发性毒性反应。高压氧治疗 (HBOT) 已被用作辐射损伤的治疗方法数十年，许多出版物都提供了来自小系列或个别病例的数据。此外，我们知道肿瘤的缺氧区域对辐射更具抵抗力。HBOT 增加了组织中的氧张力，从理论上讲，它应该提高放疗的效率。为了更好地了解 HBOT 的工作原理，我们进行了这项文献复习。我们发现 B 级和 C 级证据表明，在超过 2 绝对大气压 (ata) 的压力下，HBOT 可减少头颈部、骨骼、前列腺和膀胱的迟发性放射性损伤。它似乎还可以预防照射区域拔牙后的放射性骨坏死。最后，2 ata 的 HBOT 增加了头颈部肿瘤的放疗效果，并在高级别胶质瘤的局部控制方面取得了有希望的结果。
