Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800 Kgs. Lyngby, Denmark.
Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, I-25123 Brescia, Italy.
J Nat Prod. 2021 Apr 23;84(4):979-985. doi: 10.1021/acs.jnatprod.0c00866. Epub 2021 Mar 3.
Five new polyketides were isolated from the rare filamentous fungus IBT 16748 including calidiol A (); three phthalide derivatives califuranones A, A, and B (-); and a pair of enantiomers (-)-calitetralintriol A (-) and (+)-calitetralintriol A (+) together with four known metabolites (-). The structures of the new products were established by extensive spectroscopic analyses including HRMS and 1D and 2D NMR. The absolute configurations of two diastereomers and and the enantiomers (-) and (+) were assigned by comparing their experimental and calculated ECD data, whereas the absolute configuration of was proposed by analogy. Compound showed moderate activity against methicillin-resistant .
从稀有丝状真菌 IBT 16748 中分离得到 5 种新的聚酮化合物，包括 calidiol A (); 3 种邻苯二甲酸衍生物 califuranones A、A 和 B (-); 一对对映异构体 (-)-calitetralintriol A (-) 和 (+)-calitetralintriol A (+) 以及 4 种已知代谢物 (-)。通过 HRMS 和 1D 和 2D NMR 等广泛的光谱分析确定了新产品的结构。通过比较两种非对映异构体 和 以及对映异构体 (-)和 (+)的实验和计算 ECD 数据，确定了它们的绝对构型，而 的绝对构型则通过类推法提出。化合物 对耐甲氧西林的 显示出中等的活性。
