巴西洋葱伯克霍尔德氏菌分离株中发现携带 aac(6')-Ib-cr 基因。
First report of the aac(6')-Ib-cr gene in Providencia stuartii isolates in Brazil.
机构信息
Universidade Federal de Pernambuco, Centro de Biociências, Departamento de Bioquímica, Recife, PE, Brasil.
Universidade Federal de Pernambuco, Centro de Ciências Médicas, Departamento de Medicina Tropical, Recife, PE, Brasil.
出版信息
Rev Soc Bras Med Trop. 2020 Nov 13;54:e20190524. doi: 10.1590/0037-8682-0524-2019. eCollection 2020.
INTRODUCTION
The aac(6')-Ib-cr and bla KPC genes are spreading among Enterobacteriaceae species, including Providencia stuartii, in some countries of world.
METHODS
These genes were investigated in 28 P. stuartii isolates from a public hospital in Recife, Pernambuco, Brazil, by PCR and sequencing.
RESULTS
The aac(6')-Ib-cr gene was detected in 16 resistant isolates, and the bla KPC gene was seen in 14.
CONCLUSIONS
The presence of these genes in P. stuartii multi- and extensively drug-resistant isolates indicates that the resistance arsenal of this species is increasing, thus limiting the therapeutic options.
简介
在一些国家，包括斯氏普罗威登斯菌在内的肠杆菌科细菌正在传播 aac(6')-Ib-cr 和 bla KPC 基因。
方法
本研究通过 PCR 和测序调查了来自巴西累西腓市一家公立医院的 28 株斯氏普罗威登斯菌分离株中的这些基因。
结果
在 16 株耐药分离株中检测到 aac(6')-Ib-cr 基因，在 14 株中检测到 bla KPC 基因。
结论
这些基因在多重和广泛耐药的斯氏普罗威登斯菌分离株中的存在表明该物种的耐药 arsenal正在增加，从而限制了治疗选择。
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