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巴西玛瑙斯的 HTLV-2 感染：西亚马逊地区城区首例 HTLV-2c 亚型描述。

HTLV-2 infection in Manaus, Brazil: first description of HTLV-2c subtype in an urban area of the Western Amazon region.

机构信息

Instituto Nacional de Pesquisa da Amazônia, Manaus, AM, Brasil.

Universidade do Estado do Amazonas, Programa de Pós-graduação Stricto Sensu em Hematologia, Manaus, AM, Brasil.

出版信息

Rev Soc Bras Med Trop. 2020 Nov 13;54:e20200066. doi: 10.1590/0037-8682-0066-2020. eCollection 2020.

DOI:10.1590/0037-8682-0066-2020
PMID:33206874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7670738/
Abstract

INTRODUCTION

We investigated the prevalence of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/2) infection in patients with hematological diseases from the western Amazon region of Brazil.

METHODS

Samples from 306 patients were submitted for the molecular diagnosis of HTLV-1/2 infection by real time PCR (qPCR), with amplification, sequencing, and phylogenetic analysis of the long terminal repeat (LTR) region.

RESULTS

A 29-year-old male carrier of sickle cell anemia with a history of multiple blood transfusions was diagnosed with the HTLV-2c subtype.

CONCLUSIONS

This study describes the first known occurrence of HTLV-2c in the urban area of Brazil's western Amazon region.

摘要

简介

我们调查了巴西西部亚马逊地区血液系统疾病患者中人类 T 细胞嗜淋巴细胞病毒 1 型和 2 型（HTLV-1/2）的感染率。

方法

通过实时聚合酶链反应（qPCR）对 306 例患者的样本进行 HTLV-1/2 感染的分子诊断，对长末端重复（LTR）区进行扩增、测序和系统进化分析。

结果

一名 29 岁男性镰状细胞贫血患者，有多次输血史，被诊断为 HTLV-2c 亚型。

结论

本研究描述了巴西西部亚马逊地区首例已知的 HTLV-2c 感染。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac1/7670738/0f9f5c522c7b/1678-9849-rsbmt-54-e20200066-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac1/7670738/3e3067634ff5/1678-9849-rsbmt-54-e20200066-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac1/7670738/0f9f5c522c7b/1678-9849-rsbmt-54-e20200066-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac1/7670738/3e3067634ff5/1678-9849-rsbmt-54-e20200066-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ac1/7670738/0f9f5c522c7b/1678-9849-rsbmt-54-e20200066-gf2.jpg

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