庆大霉素与克林霉素或氯霉素联合使用对大肠杆菌和脆弱拟杆菌的杀菌活性。
Bactericidal activity of the combinations of gentamicin with clindamycin or chloramphenicol against species of Escherichia coli and Bacteroides fragilis.
作者信息
Klastersky J, Husson M
出版信息
Antimicrob Agents Chemother. 1977 Aug;12(2):135-8. doi: 10.1128/AAC.12.2.135.
Abstract
The bactericidal activity of clindamycin, chloramphenicol, and gentamicin alone and of gentamicin plus clindamycin and gentamicin plus chloramphenicol was studied on 8 strains of Escherichia coli and 10 strains of Bacteroides fragilis isolated from clinical material. Gentamicin did not interfere with the activity of clindamycin or chloramphenicol against B. fragilis. The activity of gentamicin against E. coli was not influenced by clindamycin, but chloramphenicol suppressed the rapid bactericidal activity of gentamicin in seven out of eight strains of E. coli examined.
摘要
对从临床材料中分离出的8株大肠杆菌和10株脆弱拟杆菌，研究了克林霉素、氯霉素和庆大霉素单独使用时的杀菌活性，以及庆大霉素加克林霉素和庆大霉素加氯霉素的杀菌活性。庆大霉素不影响克林霉素或氯霉素对脆弱拟杆菌的活性。克林霉素不影响庆大霉素对大肠杆菌的活性，但在8株受检大肠杆菌中，有7株氯霉素抑制了庆大霉素的快速杀菌活性。
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