Freitas Ana R, Pereira Ana P, Novais Carla, Peixe Luísa
UCIBIO/REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal.
UCIBIO/REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Jorge Viterbo Ferreira n° 228, 4050-313 Porto, Portugal.
Int J Antimicrob Agents. 2021 Jan;57(1):106227. doi: 10.1016/j.ijantimicag.2020.106227. Epub 2020 Nov 15.
Enterococcus faecium is a significant opportunistic human pathogen with a broad host range, including humans, farm animals, pets and wildlife. Specialised subpopulations have globally evolved towards a powerful and convergent adaption to the healthcare environment by acquiring a cocktail of key antimicrobial resistance and virulence genes, enabling them to thrive in the disturbed microbiota of hospitalised patients. These populations can also be found in different community reservoirs, but the relevance of their dispersal in non-human hosts is greatly unknown and is here discussed. This review provides a brief historical overview of what we have been considering E. faecium high-risk clones worldwide alongside the advances in strain typing technologies that have revolutionised our understanding of the genetic evolution of this species over the last three decades.
屎肠球菌是一种重要的机会性人类病原体，宿主范围广泛，包括人类、农场动物、宠物和野生动物。通过获得一系列关键的抗菌抗性和毒力基因，专门的亚群在全球范围内已进化出对医疗环境强大且趋同的适应性，使其能够在住院患者紊乱的微生物群中茁壮成长。这些菌群也可在不同的社区宿主中发现，但它们在非人类宿主中的传播相关性仍知之甚少，本文将对此进行讨论。本综述简要介绍了我们一直认为的全球屎肠球菌高风险克隆的历史概况，以及在过去三十年中彻底改变了我们对该物种遗传进化理解的菌株分型技术进展。
