Konstantinidis Theocharis, Tsigalou Christina, Karvelas Alexandros, Stavropoulou Elisavet, Voidarou Chrissoula, Bezirtzoglou Eugenia
Laboratory of Microbiology, Medical School, Democritus University of Thrace, Dragana, 68100 Alexandroupolis, Greece.
Centre Hospitalier Universitaire Vaudois (CHUV), Rue du Bugnon, Vaud, CH-1011 Lausanne, Switzerland.
Biomedicines. 2020 Nov 16;8(11):502. doi: 10.3390/biomedicines8110502.
The human gastrointestinal tract carries a large number of microorganisms associated with complex metabolic processes and interactions. Although antibiotic treatment is crucial for combating infections, its negative effects on the intestinal microbiota and host immunity have been shown to be of the utmost importance. Multiple studies have recognized the adverse consequences of antibiotic use upon the gut microbiome in adults and neonates, causing dysbiosis of the microbiota. Repeated antibiotic treatments in clinical care or low-dosage intake from food could be contributing factors in this issue. Researchers in both human and animal studies have strived to explain this multifaceted relationship. The present review intends to elucidate the axis of the gastrointestinal microbiota and antibiotics resistance and to highlight the main aspects of the issue.
人类胃肠道携带着大量与复杂代谢过程和相互作用相关的微生物。尽管抗生素治疗对于对抗感染至关重要，但其对肠道微生物群和宿主免疫力的负面影响已被证明至关重要。多项研究已经认识到抗生素使用对成人和新生儿肠道微生物群的不良后果，导致微生物群失调。临床护理中的反复抗生素治疗或食物中的低剂量摄入可能是这个问题的促成因素。人类和动物研究中的研究人员都努力解释这种多方面的关系。本综述旨在阐明胃肠道微生物群与抗生素耐药性的轴，并突出该问题的主要方面。
