云南黄皮中两个新的类黄酮及其细胞毒性评价。
Two Novel Flavonoids and Cytotoxicity Evaluation from Cryptocarya yunnanensis.
机构信息
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, P. R. China.
Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P. R. China.
出版信息
Chem Biodivers. 2022 Jun;19(6):e202200224. doi: 10.1002/cbdv.202200224. Epub 2022 May 13.
Two new flavonoids, cryunchalcone (1) and cryptoyunnanone I (2), were isolated from the leaves and twigs of Cryptocarya yunnanensis. Their structures were elucidated by the detailed spectroscopic data analysis and electronic circular dichroism (ECD) calculations. Cryunchalcone (1) is a biflavonoid constructed by a dihydrochalcone coupled with a chalcone through an unprecedented C-2''-C-6 linkage. Cryptoyunnanone I (2) is a unique complex flavanone bearing a phenylpropanoid moiety.
从云南钩栲的叶和小枝中分离得到两个新的类黄酮化合物，即 cryunchalcone（1）和 cryptoyunnanone I（2）。通过详细的光谱数据分析和电子圆二色性（ECD）计算确定了它们的结构。Cryunchalcone（1）是由二氢查耳酮通过前所未有的 C-2''-C-6 键与查耳酮偶联而成的双黄酮。Cryptoyunnanone I（2）是一种具有苯丙素部分的独特复杂黄烷酮。
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