体外膈肌起搏治疗慢性肺源性心脏病的随机对照研究。
Effect of external diaphragmatic pacing therapy on patients with chronic cor pulmonale: a randomized, controlled trial.
机构信息
Department of Critical Care Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
Emergency Department, Kashgar Prefecture Second People's Hospital, Kashgar, Xinjiang, China.
出版信息
J Int Med Res. 2020 Nov;48(11):300060520965839. doi: 10.1177/0300060520965839.
OBJECTIVES
This study aimed to evaluate the effects of external diaphragmatic pacing (EDP) on patients with chronic cor pulmonale (CCP).
METHODS
Fifty patients with CCP were enrolled in Kashgar Prefecture Second People's Hospital in Xinjiang Uygur Autonomous Region of China from 2016 to 2017. The patients were randomized into a group that received anti-CCP therapy (negative control group) or a group that received additional EDP treatment (EDP group). We recorded and compared maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC, and the 6-minute walking test between the two groups on the first and tenth days of treatment.
RESULTS
Ten days after treatment began, MIP, FVC, and the 6-minute walking test were significantly improved in both groups. Importantly, MIP and FVC were significantly higher in the EDP group compared with the control group on the tenth day.
CONCLUSION
In addition to treatment for CCP, these patients can obtain extra benefit by using EDP treatment.
目的
本研究旨在评估体外膈肌起搏（EDP）对慢性肺源性心脏病（CCP）患者的影响。
方法
2016 年至 2017 年，本研究纳入了来自中国新疆维吾尔自治区喀什地区第二人民医院的 50 例 CCP 患者。患者被随机分为接受抗 CCP 治疗的组（阴性对照组）或接受附加 EDP 治疗的组（EDP 组）。我们记录并比较了两组患者在治疗的第 1 天和第 10 天的最大吸气压力（MIP）、最大呼气压力（MEP）、1 秒用力呼气量（FEV1）、用力肺活量（FVC）、FEV1/FVC 和 6 分钟步行试验。
结果
治疗开始后 10 天，两组患者的 MIP、FVC 和 6 分钟步行试验均明显改善。重要的是，EDP 组患者的 MIP 和 FVC 在第 10 天明显高于对照组。
结论
除了 CCP 的治疗外，这些患者还可以通过使用 EDP 治疗获得额外的益处。
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