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mA modification-mediated CBX8 induction regulates stemness and chemosensitivity of colon cancer via upregulation of LGR5.mA 修饰介导的 CBX8 诱导通过上调 LGR5 调节结肠癌的干性和化疗敏感性。
Mol Cancer. 2019 Dec 18;18(1):185. doi: 10.1186/s12943-019-1116-x.
2
CBX4 promotes the proliferation and metastasis via regulating BMI-1 in lung cancer.CBX4 通过调节 BMI-1 促进肺癌的增殖和转移。
J Cell Mol Med. 2020 Jan;24(1):618-631. doi: 10.1111/jcmm.14771. Epub 2019 Nov 13.
3
CBX7 Inhibits Cell Growth and Motility and Induces Apoptosis in Cervical Cancer Cells.CBX7抑制宫颈癌细胞的生长和运动并诱导其凋亡。
Mol Ther Oncolytics. 2019 Sep 24;15:108-116. doi: 10.1016/j.omto.2019.09.002. eCollection 2019 Dec 20.
4
The reactome pathway knowledgebase.Reactome 通路知识库。
Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503. doi: 10.1093/nar/gkz1031.
5
Predictive and Prognostic Factors in HCC Patients Treated with Sorafenib.索拉非尼治疗 HCC 患者的预测和预后因素。
Medicina (Kaunas). 2019 Oct 21;55(10):707. doi: 10.3390/medicina55100707.
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CBX3 promotes glioma U87 cell proliferation and predicts an unfavorable prognosis.CBX3 促进脑胶质瘤 U87 细胞增殖并预测不良预后。
J Neurooncol. 2019 Oct;145(1):35-48. doi: 10.1007/s11060-019-03286-w. Epub 2019 Sep 9.
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Chromobox homolog 8 (CBX8) Interacts with Y-Box binding protein 1 (YBX1) to promote cellular proliferation in hepatocellular carcinoma cells.染色体盒同源物8（CBX8）与Y盒结合蛋白1（YBX1）相互作用，以促进肝癌细胞的细胞增殖。
Aging (Albany NY). 2019 Sep 8;11(17):7123-7149. doi: 10.18632/aging.102241.
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Cancers (Basel). 2019 Jul 4;11(7):942. doi: 10.3390/cancers11070942.
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CBX8 promotes tumorigenesis and confers radioresistance in esophageal squamous cell carcinoma cells through targeting APAF1.CBX8 通过靶向 APAF1 促进食管鳞癌细胞的肿瘤发生和放射抵抗。
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胃癌中染色体框家族预后的综合分析。

Comprehensive analysis of the prognosis for chromobox family in gastric cancer.

作者信息

Lin Kang, Zhu Jinfeng, Hu Cegui, Bu Fanqin, Luo Chen, Zhu Xiaojian, Zhu Zhengming

机构信息

Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

出版信息

J Gastrointest Oncol. 2020 Oct;11(5):932-951. doi: 10.21037/jgo-20-208.

DOI:10.21037/jgo-20-208
PMID:33209489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7657827/
Abstract

BACKGROUND

Chromobox (CBX) family proteins are a class of transcriptional repressors involved in epigenetic regulation and developmental processes of various tumors, including gastric cancer. However, the function and prognosis of different CBXs in gastric cancer remain unknown.

METHODS

This study addresses this issue by synthesizing several mainstream databases (Oncomine, GEPIA2, cBioportal, and Kaplan-Meier plotter, among others) that currently contain many tumor samples and provide very reliable analysis results, investigating the role of CBXs in the prognosis of gastric cancer.

RESULTS

The mRNA of CBX1/2/3/4/5/8 was highly expressed in gastric cancer, the mRNA of CBX7 was lowly expressed in gastric cancer, and the mRNA expression of CBX6 was not significantly different in CRC. Besides, high and low CBXs mRNA expression correlated with cancer stage, node metastasis status, infection status, and tumor grade in CRC patients. We found that high mRNA expression of CBX4/5/6/7/8 was significantly associated with worse overall survival (OS), progression-free survival (FP), and post-progression survival (PPS) in a large number of CRC patients. High mRNA expression of CBX3 was significantly associated with better OS and FP. We also found that none of the eight CBXs family genes had a mutation rate of less than 5% in gastric cancer, and the highest mutation rate was in CBX3 (14%).

CONCLUSIONS

These results suggest that CBX3/4/5/6/7/8 could be a prognostic biomarker in gastric cancer patients.

摘要

背景

染色质盒（CBX）家族蛋白是一类转录抑制因子，参与包括胃癌在内的多种肿瘤的表观遗传调控和发育过程。然而，不同CBX在胃癌中的功能和预后仍不清楚。

方法

本研究通过综合几个主流数据库（如Oncomine、GEPIA2、cBioportal和Kaplan-Meier plotter等）来解决这一问题，这些数据库目前包含许多肿瘤样本并提供非常可靠的分析结果，以研究CBX在胃癌预后中的作用。

结果

CBX1/2/3/4/5/8的mRNA在胃癌中高表达，CBX7的mRNA在胃癌中低表达，CBX6的mRNA在结直肠癌中的表达无显著差异。此外，CBXs mRNA的高低表达与结直肠癌患者的癌症分期、淋巴结转移状态、感染状态和肿瘤分级相关。我们发现，在大量结直肠癌患者中，CBX4/5/6/7/8的高mRNA表达与较差的总生存期（OS）、无进展生存期（FP）和进展后生存期（PPS）显著相关。CBX3的高mRNA表达与较好的OS和FP显著相关。我们还发现，八个CBX家族基因在胃癌中的突变率均不低于5%，其中CBX3的突变率最高（14%）。

结论

这些结果表明，CBX3/4/5/6/7/8可能是胃癌患者的预后生物标志物。