胃癌中染色体框家族预后的综合分析。
Comprehensive analysis of the prognosis for chromobox family in gastric cancer.
作者信息
Lin Kang, Zhu Jinfeng, Hu Cegui, Bu Fanqin, Luo Chen, Zhu Xiaojian, Zhu Zhengming
机构信息
Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
出版信息
J Gastrointest Oncol. 2020 Oct;11(5):932-951. doi: 10.21037/jgo-20-208.
BACKGROUND
Chromobox (CBX) family proteins are a class of transcriptional repressors involved in epigenetic regulation and developmental processes of various tumors, including gastric cancer. However, the function and prognosis of different CBXs in gastric cancer remain unknown.
METHODS
This study addresses this issue by synthesizing several mainstream databases (Oncomine, GEPIA2, cBioportal, and Kaplan-Meier plotter, among others) that currently contain many tumor samples and provide very reliable analysis results, investigating the role of CBXs in the prognosis of gastric cancer.
RESULTS
The mRNA of CBX1/2/3/4/5/8 was highly expressed in gastric cancer, the mRNA of CBX7 was lowly expressed in gastric cancer, and the mRNA expression of CBX6 was not significantly different in CRC. Besides, high and low CBXs mRNA expression correlated with cancer stage, node metastasis status, infection status, and tumor grade in CRC patients. We found that high mRNA expression of CBX4/5/6/7/8 was significantly associated with worse overall survival (OS), progression-free survival (FP), and post-progression survival (PPS) in a large number of CRC patients. High mRNA expression of CBX3 was significantly associated with better OS and FP. We also found that none of the eight CBXs family genes had a mutation rate of less than 5% in gastric cancer, and the highest mutation rate was in CBX3 (14%).
CONCLUSIONS
These results suggest that CBX3/4/5/6/7/8 could be a prognostic biomarker in gastric cancer patients.
背景
染色质盒（CBX）家族蛋白是一类转录抑制因子，参与包括胃癌在内的多种肿瘤的表观遗传调控和发育过程。然而，不同CBX在胃癌中的功能和预后仍不清楚。
方法
本研究通过综合几个主流数据库（如Oncomine、GEPIA2、cBioportal和Kaplan-Meier plotter等）来解决这一问题，这些数据库目前包含许多肿瘤样本并提供非常可靠的分析结果，以研究CBX在胃癌预后中的作用。
结果
CBX1/2/3/4/5/8的mRNA在胃癌中高表达，CBX7的mRNA在胃癌中低表达，CBX6的mRNA在结直肠癌中的表达无显著差异。此外，CBXs mRNA的高低表达与结直肠癌患者的癌症分期、淋巴结转移状态、感染状态和肿瘤分级相关。我们发现，在大量结直肠癌患者中，CBX4/5/6/7/8的高mRNA表达与较差的总生存期（OS）、无进展生存期（FP）和进展后生存期（PPS）显著相关。CBX3的高mRNA表达与较好的OS和FP显著相关。我们还发现，八个CBX家族基因在胃癌中的突变率均不低于5%，其中CBX3的突变率最高（14%）。
结论
这些结果表明，CBX3/4/5/6/7/8可能是胃癌患者的预后生物标志物。
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