Meis J F, Ponnudurai T
Department of Medical Parasitology, University of Nijmegen, The Netherlands.
Parasitol Res. 1987;73(6):500-6. doi: 10.1007/BF00535323.
The interaction of Plasmodium falciparum ookinetes with the midgut epithelium of Anopheles stephensi is described by electron microscopy. Plasmodium falciparum ookinetes have been traced during the early stages of invasion and localization beneath the basal lamina of the midgut. It is generally assumed that ookinetes break through two membranes to reach the basal lamina of the midgut epithelium by an intracellular route. In the present study evidence is presented that the ookinete takes an intercellular route in traversing the epithelial layer. Compared to the mode of penetration and intracellular development of sporozoites and merozoites, an intercellular route for penetration of the ookinete is not inconsistent with its further extracellular development.
利用电子显微镜描述了恶性疟原虫动合子与斯氏按蚊中肠上皮细胞的相互作用。在动合子侵入中肠基膜下并定位的早期阶段对其进行了追踪。一般认为动合子通过细胞内途径穿过两层膜到达中肠上皮的基膜。在本研究中，有证据表明动合子在穿过上皮层时采用细胞间途径。与子孢子和裂殖子的穿透方式及细胞内发育相比，动合子的细胞间穿透途径与其进一步的细胞外发育并不矛盾。
