Kinlen L J
CRC Cancer Epidemiology Unit, University of Edinburgh, U.K.
Prog Lipid Res. 1986;25(1-4):527-31. doi: 10.1016/0163-7827(86)90107-4.
Strongly positive correlations exist between the incidence of breast and large bowel cancers in different countries and the corresponding per caput intake of fat. However, attempts to confirm these relationships have, on the whole, proved disappointing, in studies of individuals whether using the case-control or the prospective approach. Moreover no positive relationship is evident in prospective studies between blood lipid levels and colon or breast cancers. Overall the human evidence for fat as a cause of these cancers is weak. Possible reasons are considered for the findings in different studies.
在不同国家，乳腺癌和大肠癌的发病率与相应的人均脂肪摄入量之间存在着强正相关。然而，总体而言，无论是采用病例对照研究还是前瞻性研究方法，在对个体的研究中，试图证实这些关系的尝试都令人失望。此外，在前瞻性研究中，血脂水平与结肠癌或乳腺癌之间没有明显的正相关关系。总体而言，关于脂肪是这些癌症病因的人体证据不足。针对不同研究中的发现，人们考虑了可能的原因。
